Detecting Immune Response to Therapies Targeting PDL1 and BRAF by Using Ferumoxytol MRI and Macrin in Anaplastic Thyroid Cancer.

Animals Antibodies, Monoclonal, Humanized / immunology Antineoplastic Agents / immunology B7-H1 Antigen / antagonists & inhibitors Cell Line, Tumor Disease Models, Animal Female Ferrosoferric Oxide Immunity / immunology Magnetic Resonance Imaging / methods Mice Nanoparticles Proto-Oncogene Proteins B-raf / antagonists & inhibitors Thyroid Carcinoma, Anaplastic / diagnostic imaging Tumor-Associated Macrophages / immunology

Journal

Radiology
ISSN: 1527-1315
Titre abrégé: Radiology
Pays: United States
ID NLM: 0401260

Informations de publication

Date de publication:
01 2021
Historique:
pubmed: 28 10 2020
medline: 27 4 2021
entrez: 27 10 2020
Statut: ppublish

Résumé

Background Anaplastic thyroid cancer (ATC) is aggressive with a poor prognosis, partly because of the immunosuppressive microenvironment created by tumor-associated macrophages (TAMs). Purpose To understand the relationship between TAM infiltration, tumor vascularization, and corresponding drug delivery by using ferumoxytol-enhanced MRI and macrin in an ATC mouse model. Materials and Methods ATC tumors were generated in 6-8-week-old female B6129SF1/J mice through intrathyroid injection to model orthotopic tumors, or intravenously to model hematogenous metastasis, and prospectively enrolled randomly into treatment cohorts (

Identifiants

DOI: 10.1148/radiol.2020201791 PMID: 33107799 PMC: PMC7771993
pubmed: 33107799
doi: 10.1148/radiol.2020201791
pmc: PMC7771993
mid: NIHMS1658248
doi:

Substances chimiques

Antibodies, Monoclonal, Humanized 0
Antineoplastic Agents 0
B7-H1 Antigen 0
atezolizumab 52CMI0WC3Y
Proto-Oncogene Proteins B-raf EC 2.7.11.1
Ferrosoferric Oxide XM0M87F357

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

123-132

Subventions

Organisme : NCI NIH HHS
ID : T32 CA079443
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA206997
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA257623
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA206890
Pays : United States
Organisme : NCI NIH HHS
ID : R00 CA207744
Pays : United States

Commentaires et corrections

Type : CommentIn

Références

Clin Cancer Res. 2017 Sep 1;23(17):5024-5033
pubmed: 28512174
Cell. 2017 Nov 2;171(4):934-949.e16
pubmed: 29033130
Med Mol Morphol. 2018 Mar;51(1):57-63
pubmed: 29218457
Br J Cancer. 2018 Nov;119(10):1223-1232
pubmed: 30327563
Oncotarget. 2016 Mar 29;7(13):17194-211
pubmed: 26943572
Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7750-5
pubmed: 27342857
Immunity. 2016 Feb 16;44(2):343-54
pubmed: 26872698
ACS Nano. 2018 Dec 26;12(12):12015-12029
pubmed: 30508377
Oncotarget. 2014 Jun 30;5(12):3996-4010
pubmed: 24994118
Sci Transl Med. 2017 May 31;9(392):
pubmed: 28566423
Sci Adv. 2020 May 22;6(21):eaaz8521
pubmed: 32494745
Nanotheranostics. 2017 Jul 6;1(3):296-312
pubmed: 29071194
Magn Reson Med. 2018 Sep;80(3):1138-1147
pubmed: 29327789
Int J Endocrinol. 2019 Feb 19;2019:8428547
pubmed: 30915116
Lab Anim Sci. 1999 Jun;49(3):319-23
pubmed: 10403450
Endocr Relat Cancer. 2008 Dec;15(4):1069-74
pubmed: 18719091
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
PLoS One. 2013 Aug 28;8(8):e73215
pubmed: 24015297
AJNR Am J Neuroradiol. 2018 Mar;39(3):547-551
pubmed: 29242360
Per Med. 2011 Mar;8(2):175-182
pubmed: 29783410
Clin Cancer Res. 2017 Jul 15;23(14):3638-3648
pubmed: 28159813
Cancer Cell. 2017 Nov 13;32(5):654-668.e5
pubmed: 29136508
Adv Drug Deliv Rev. 2015 Aug 30;91:3-6
pubmed: 25579058
J Clin Oncol. 2018 Jan 1;36(1):7-13
pubmed: 29072975
Nat Commun. 2017 Feb 08;8:14293
pubmed: 28176769
Clin Cancer Res. 2018 Sep 1;24(17):4110-4118
pubmed: 29764855
Sci Transl Med. 2017 May 10;9(389):
pubmed: 28490665
Thyroid. 2019 Jul;29(7):979-992
pubmed: 30938231
Int J Cancer. 1988 Apr 15;41(4):562-7
pubmed: 3128489
Nat Biomed Eng. 2018 Aug;2(8):578-588
pubmed: 31015631
Thyroid. 2017 May;27(5):672-681
pubmed: 28068873
Nat Commun. 2015 Oct 27;6:8692
pubmed: 26503691
Sci Transl Med. 2015 Nov 18;7(314):314ra183
pubmed: 26582898
BMC Med Imaging. 2015 Jun 16;15:19
pubmed: 26076957

Auteurs

Thomas S C Ng (TSC)

From the Center for Systems Biology, Massachusetts General Hospital Research Institute, 185 Cambridge St, Suite 5.210, Boston, MA 02114 (T.S.C.N., R.L., M.P., Y.I., R.H.K., R.W., M.A.M.); Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass (T.S.C.N.); Departments of Surgery (V.G., S.P.) and Radiology (R.L., R.W., M.A.M.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and Department of Systems Biology, Harvard Medical School, Boston, Mass (R.W.).
ORCID: 0000-0002-3676-1800

Viswanath Gunda (V)

From the Center for Systems Biology, Massachusetts General Hospital Research Institute, 185 Cambridge St, Suite 5.210, Boston, MA 02114 (T.S.C.N., R.L., M.P., Y.I., R.H.K., R.W., M.A.M.); Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass (T.S.C.N.); Departments of Surgery (V.G., S.P.) and Radiology (R.L., R.W., M.A.M.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and Department of Systems Biology, Harvard Medical School, Boston, Mass (R.W.).

Ran Li (R)

From the Center for Systems Biology, Massachusetts General Hospital Research Institute, 185 Cambridge St, Suite 5.210, Boston, MA 02114 (T.S.C.N., R.L., M.P., Y.I., R.H.K., R.W., M.A.M.); Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass (T.S.C.N.); Departments of Surgery (V.G., S.P.) and Radiology (R.L., R.W., M.A.M.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and Department of Systems Biology, Harvard Medical School, Boston, Mass (R.W.).
ORCID: 0000-0002-8537-8824

Mark Prytyskach (M)

From the Center for Systems Biology, Massachusetts General Hospital Research Institute, 185 Cambridge St, Suite 5.210, Boston, MA 02114 (T.S.C.N., R.L., M.P., Y.I., R.H.K., R.W., M.A.M.); Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass (T.S.C.N.); Departments of Surgery (V.G., S.P.) and Radiology (R.L., R.W., M.A.M.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and Department of Systems Biology, Harvard Medical School, Boston, Mass (R.W.).

Yoshiko Iwamoto (Y)

From the Center for Systems Biology, Massachusetts General Hospital Research Institute, 185 Cambridge St, Suite 5.210, Boston, MA 02114 (T.S.C.N., R.L., M.P., Y.I., R.H.K., R.W., M.A.M.); Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass (T.S.C.N.); Departments of Surgery (V.G., S.P.) and Radiology (R.L., R.W., M.A.M.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and Department of Systems Biology, Harvard Medical School, Boston, Mass (R.W.).
ORCID: 0000-0002-3723-1043

Rainer H Kohler (RH)

From the Center for Systems Biology, Massachusetts General Hospital Research Institute, 185 Cambridge St, Suite 5.210, Boston, MA 02114 (T.S.C.N., R.L., M.P., Y.I., R.H.K., R.W., M.A.M.); Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass (T.S.C.N.); Departments of Surgery (V.G., S.P.) and Radiology (R.L., R.W., M.A.M.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and Department of Systems Biology, Harvard Medical School, Boston, Mass (R.W.).
ORCID: 0000-0001-6269-6590

Sareh Parangi (S)

From the Center for Systems Biology, Massachusetts General Hospital Research Institute, 185 Cambridge St, Suite 5.210, Boston, MA 02114 (T.S.C.N., R.L., M.P., Y.I., R.H.K., R.W., M.A.M.); Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass (T.S.C.N.); Departments of Surgery (V.G., S.P.) and Radiology (R.L., R.W., M.A.M.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and Department of Systems Biology, Harvard Medical School, Boston, Mass (R.W.).

Ralph Weissleder (R)

From the Center for Systems Biology, Massachusetts General Hospital Research Institute, 185 Cambridge St, Suite 5.210, Boston, MA 02114 (T.S.C.N., R.L., M.P., Y.I., R.H.K., R.W., M.A.M.); Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass (T.S.C.N.); Departments of Surgery (V.G., S.P.) and Radiology (R.L., R.W., M.A.M.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and Department of Systems Biology, Harvard Medical School, Boston, Mass (R.W.).
ORCID: 0000-0003-0828-4143

Miles A Miller (MA)

From the Center for Systems Biology, Massachusetts General Hospital Research Institute, 185 Cambridge St, Suite 5.210, Boston, MA 02114 (T.S.C.N., R.L., M.P., Y.I., R.H.K., R.W., M.A.M.); Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass (T.S.C.N.); Departments of Surgery (V.G., S.P.) and Radiology (R.L., R.W., M.A.M.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and Department of Systems Biology, Harvard Medical School, Boston, Mass (R.W.).
ORCID: 0000-0001-7638-8898

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Detecting Immune Response to Therapies...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Anticorps monoclonaux humanisés › Detecting Immune Response to Therapies...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Detecting Immune Response to Therapies...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Antigènes B7 › Antigène CD274 › Detecting Immune Response to Therapies...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Detecting Immune Response to Therapies...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Detecting Immune Response to Therapies...
questionsmedicales.fr › Produits chimiques inorganiques › Minéraux › Oxyde ferrosoferrique › Detecting Immune Response to Therapies...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Detecting Immune Response to Therapies...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Detecting Immune Response to Therapies...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Detecting Immune Response to Therapies...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Detecting Immune Response to Therapies...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Kinases raf › Protéines proto-oncogènes B-raf › Detecting Immune Response to Therapies...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Carcinomes › Carcinome anaplasique de la thyroïde › Detecting Immune Response to Therapies...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Macrophages associés aux tumeurs › Detecting Immune Response to Therapies...