Sperm DNA fragmentation testing: Summary evidence and clinical practice recommendations.
assisted reproductive technology
male infertility
practice guideline
semen analysis
sperm DNA fragmentation
Journal
Andrologia
ISSN: 1439-0272
Titre abrégé: Andrologia
Pays: Germany
ID NLM: 0423506
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
25
06
2020
revised:
06
09
2020
accepted:
13
09
2020
pubmed:
28
10
2020
medline:
22
6
2021
entrez:
27
10
2020
Statut:
ppublish
Résumé
We herein summarise the evidence concerning the impact of sperm DNA fragmentation in various clinical infertility scenarios and the advances on sperm DNA fragmentation tests. The collected evidence was used to formulate 41 recommendations. Of these, 13 recommendations concern technical aspects of sperm DNA fragmentation testing, including pre-analytical information, clinical thresholds and interpretation of results. The remaining 28 recommendations relate to indications for sperm DNA fragmentation testing and clinical management. Clinical scenarios like varicocele, unexplained infertility, idiopathic infertility, recurrent pregnancy loss, intrauterine insemination, in vitro fertilisation/intracytoplasmic sperm injection, fertility counselling for men with infertility risk factors and sperm cryopreservation have been contemplated. The bulk evidence supporting the recommendations has increased in recent years, but it is still of moderate to low quality. This guideline provides clinicians with advice on best practices in sperm DNA fragmentation testing. Also, recommendations are provided on possible management strategies to overcome infertility related to sperm DNA fragmentation, based on the best available evidence. Lastly, we identified gaps in knowledge and opportunities for research and elaborated a list of recommendations to stimulate further investigation.
Identifiants
pubmed: 33108829
doi: 10.1111/and.13874
pmc: PMC7988559
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13874Informations de copyright
© 2020 The Authors. Andrologia published by Wiley-VCH GmbH.
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