Influence of p16 status on indication and outcome of salvage neck dissection in oropharyngeal cancer.
HPV
Oropharyngeal cancer
de-escalation
p16
radiochemotherapy
Journal
Acta oto-laryngologica
ISSN: 1651-2251
Titre abrégé: Acta Otolaryngol
Pays: England
ID NLM: 0370354
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
pubmed:
29
10
2020
medline:
21
10
2021
entrez:
28
10
2020
Statut:
ppublish
Résumé
Human papillomavirus (HPV)+ and HPV- oropharyngeal squamous cell carcinomas (OPSCC) are separate tumor entities. The aim of this study was to examine if the p16 status influences the need and outcome of a salvage neck dissection (SND) after primary radiochemotherapy (pRCT). Retrospective study of 164 patients ( Of the 56 p16+ patients, 17 (30.4%) patients were given an indication for a SND after pRCT with 4 (23.5%) patients showing persistent malignant nodes. Of the 108 p16- patients, 24 (22.2%) patients underwent a SND with 8 (33.3%) patients showing persistent malignant nodes. There was no significant association of the p16 status and neither the indication for SND (p(Chi There was neither a significant association between the p16 status and the indication for a SND nor for persistent malignant nodal disease after pRCT.
Sections du résumé
BACKGROUND
BACKGROUND
Human papillomavirus (HPV)+ and HPV- oropharyngeal squamous cell carcinomas (OPSCC) are separate tumor entities.
AIMS/OBJECTIVES
OBJECTIVE
The aim of this study was to examine if the p16 status influences the need and outcome of a salvage neck dissection (SND) after primary radiochemotherapy (pRCT).
MATERIAL AND METHODS
METHODS
Retrospective study of 164 patients (
RESULTS
RESULTS
Of the 56 p16+ patients, 17 (30.4%) patients were given an indication for a SND after pRCT with 4 (23.5%) patients showing persistent malignant nodes. Of the 108 p16- patients, 24 (22.2%) patients underwent a SND with 8 (33.3%) patients showing persistent malignant nodes. There was no significant association of the p16 status and neither the indication for SND (p(Chi
CONCLUSIONS AND SIGNIFICANCE
CONCLUSIONS
There was neither a significant association between the p16 status and the indication for a SND nor for persistent malignant nodal disease after pRCT.
Identifiants
pubmed: 33108949
doi: 10.1080/00016489.2020.1831697
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM