A Comprehensive Review on DNA Gyrase Inhibitors.

Anti-Bacterial Agents / pharmacology Bacteria / drug effects DNA Gyrase Drug Resistance, Microbial / drug effects Humans Topoisomerase II Inhibitors / pharmacology
DNA gyrase inhibitors antibacterial anticancer antimalarial docking fungal infections

Journal

Infectious disorders drug targets
ISSN: 2212-3989
Titre abrégé: Infect Disord Drug Targets
Pays: United Arab Emirates
ID NLM: 101269158

Informations de publication

Date de publication:
2020
Historique:
received: 03 07 2019
revised: 12 09 2019
accepted: 15 12 2019
pubmed: 29 10 2020
medline: 10 9 2021
entrez: 28 10 2020
Statut: ppublish

Résumé

The newly emerging infectious organisms, the global crisis in antibiotic resistance, and the threat of bioterrorism create an urgent need to discover novel antimicrobial agents. In order to develop novel antimicrobial agents, the mechanism of infectious disease must be better understood. DNA Gyrase is a bacterial enzyme that plays an important role in the replication of DNA and transcription process. It is not present in higher eukaryotes making it a perfect target for developing new antibacterial agents. This review describes the role of DNA gyrase inhibitors in preventing various diseases. In this review, we outline the synthesis and pharmacological action of various novel DNA gyrase inhibitors. DNA gyrase inhibitors were used to treat tuberculosis, bacterial, fungal infections and malaria. DNA gyrase inhibitors mainly act by preventing the supercoiling of DNA strands..

Identifiants

DOI: 10.2174/1871526520666200102110235 PMID: 33109068
pubmed: 33109068
pii: IDDT-EPUB-103399
doi: 10.2174/1871526520666200102110235
doi:

Substances chimiques

Anti-Bacterial Agents 0
Topoisomerase II Inhibitors 0
DNA Gyrase EC 5.99.1.3

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

765-777

Informations de copyright

Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Auteurs

S R Chitra (SR)

Department of Pharmaceutical Chemistry, C.L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai -97, India.

N Ramalakshmi (N)

Department of Pharmaceutical Chemistry, C.L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai -97, India.

Subramani Arunkumar (S)

College of Pharmacy, Gulf Medical University, Ajmaan, United Arab Emirates.

P Manimegalai (P)

Department of Pharmaceutical Chemistry, C.L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai -97, India.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › A Comprehensive Review on DNA Gyrase Inhibitors.
questionsmedicales.fr › Bactéries › A Comprehensive Review on DNA Gyrase Inhibitors.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › DNA gyrase › A Comprehensive Review on DNA Gyrase Inhibitors.
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › A Comprehensive Review on DNA Gyrase Inhibitors.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A Comprehensive Review on DNA Gyrase Inhibitors.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Inhibiteurs des topoisomérases › Inhibiteurs de la topoisomérase-II › A Comprehensive Review on DNA Gyrase Inhibitors.