The Brabant study: design of a large prospective perinatal cohort study among pregnant women investigating obstetric outcome from a biopsychosocial perspective.
depression & mood disorders
maternal medicine
thyroid disease
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
27 10 2020
27 10 2020
Historique:
entrez:
28
10
2020
pubmed:
29
10
2020
medline:
15
5
2021
Statut:
epublish
Résumé
Pregnancy is characterised by many biological and psychosocial changes. Adequate maternal thyroid function is important for the developing fetus throughout gestation. Latent class analyses recently showed three different patterns of change in thyroid function throughout pregnancy with different associations with obstetric outcome. Maternal distress during the pregnancy (anxiety and depression) negatively affects obstetric outcome. Pregnancy distress in turn may be affected by personality traits and attachment styles. Moreover, during the pregnancy, substantial social changes occur in the partner relationship and work experience. The aim of the Brabant study is to investigate the association between thyroid function trajectories and obstetric outcomes. Moreover, within the Brabant study, we will investigate how different trajectories of pregnancy distress are related to obstetric outcome, and the role of personality in this association. We will evaluate the possible role of maternal distress and attachment style on maternal-fetal bonding. Finally, we will study social changes in the perinatal period regarding partner relationship and well-being and performance at work. The Brabant study is a longitudinal, prospective cohort study of an anticipated 4000 pregnant women. Women will be recruited at 8-10 weeks gestation among community midwife practices in South-East Brabant in the Netherlands. Thyroid function parameters (TSH and fT4), thyroid peroxidase antibody and human chorionic gonadotrophin will be assessed at 12, 20 and 28 weeks gestation. Moreover, at these three time points women will fill out questionnaires assessing demographic and obstetric features, life style habits and psychological and social variables, such as depressive symptoms, personality, partner relationship quality and burnout. Data from the obstetric records will also be collected. The study has been approved by the Medical Ethical Committee of the Máxima Medical Center Veldhoven. Results will be submitted to peer-reviewed journals in the relevant fields and presented on national and international conferences.
Sections du résumé
BACKGROUND
Pregnancy is characterised by many biological and psychosocial changes. Adequate maternal thyroid function is important for the developing fetus throughout gestation. Latent class analyses recently showed three different patterns of change in thyroid function throughout pregnancy with different associations with obstetric outcome. Maternal distress during the pregnancy (anxiety and depression) negatively affects obstetric outcome. Pregnancy distress in turn may be affected by personality traits and attachment styles. Moreover, during the pregnancy, substantial social changes occur in the partner relationship and work experience. The aim of the Brabant study is to investigate the association between thyroid function trajectories and obstetric outcomes. Moreover, within the Brabant study, we will investigate how different trajectories of pregnancy distress are related to obstetric outcome, and the role of personality in this association. We will evaluate the possible role of maternal distress and attachment style on maternal-fetal bonding. Finally, we will study social changes in the perinatal period regarding partner relationship and well-being and performance at work.
METHODS AND ANALYSIS
The Brabant study is a longitudinal, prospective cohort study of an anticipated 4000 pregnant women. Women will be recruited at 8-10 weeks gestation among community midwife practices in South-East Brabant in the Netherlands. Thyroid function parameters (TSH and fT4), thyroid peroxidase antibody and human chorionic gonadotrophin will be assessed at 12, 20 and 28 weeks gestation. Moreover, at these three time points women will fill out questionnaires assessing demographic and obstetric features, life style habits and psychological and social variables, such as depressive symptoms, personality, partner relationship quality and burnout. Data from the obstetric records will also be collected.
ETHICS AND DISSEMINATION
The study has been approved by the Medical Ethical Committee of the Máxima Medical Center Veldhoven. Results will be submitted to peer-reviewed journals in the relevant fields and presented on national and international conferences.
Identifiants
pubmed: 33109659
pii: bmjopen-2020-038891
doi: 10.1136/bmjopen-2020-038891
pmc: PMC7592269
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e038891Informations de copyright
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
J Affect Disord. 2019 Dec 1;259:175-179
pubmed: 31446377
J Matern Fetal Neonatal Med. 2007 Mar;20(3):189-209
pubmed: 17437220
JAMA. 2016 Jan 26;315(4):388-406
pubmed: 26813212
Arch Gynecol Obstet. 2016 Mar;293(3):575-82
pubmed: 26404450
Ned Tijdschr Geneeskd. 2008 Jun 7;152(23):1323-8
pubmed: 18661859
J Womens Health (Larchmt). 2003 May;12(4):373-80
pubmed: 12804344
N Engl J Med. 2012 Feb 9;366(6):493-501
pubmed: 22316443
Arch Gen Psychiatry. 2010 Oct;67(10):1012-24
pubmed: 20921117
Br J Psychiatry. 1987 Jun;150:782-6
pubmed: 3651732
J Fam Psychol. 2009 Dec;23(6):848-52
pubmed: 20001143
Obstet Gynecol. 2012 Feb;119(2 Pt 1):315-20
pubmed: 22270283
Obstet Gynecol. 2004 Sep;104(3):467-76
pubmed: 15339755
Br J Psychiatry. 2017 May;210(5):315-323
pubmed: 28302701
Clin Psychol Rev. 2000 Nov;20(8):1019-40
pubmed: 11098398
J Psychosom Res. 2011 Apr;70(4):385-9
pubmed: 21414460
Arch Womens Ment Health. 2018 Feb;21(1):117-120
pubmed: 29067550
J Psychiatr Res. 2012 Apr;46(4):469-75
pubmed: 22257387
J Pers Soc Psychol. 2009 Mar;96(3):601-619
pubmed: 19254107
JAMA. 2017 Dec 12;318(22):2190-2198
pubmed: 29234808
Midwifery. 2014 May;30(5):526-31
pubmed: 23870748
Curr Psychiatry Rep. 2015 Feb;17(2):2
pubmed: 25617042
Eur J Clin Pharmacol. 2012 May;68(5):845-51
pubmed: 22189674
Behav Sleep Med. 2016;14(1):34-48
pubmed: 25174718
Thyroid. 2014 Oct;24(10):1541-6
pubmed: 25000138
J Autism Dev Disord. 2010 Apr;40(4):470-8
pubmed: 19885724
J Adv Nurs. 2015 Sep;71(9):1986-2001
pubmed: 25818179
Pers Soc Psychol Rev. 2015 Feb;19(1):44-76
pubmed: 25024278
J Affect Disord. 1992 Oct;26(2):105-10
pubmed: 1447427
BMC Pregnancy Childbirth. 2011 Oct 26;11:80
pubmed: 22029691
J Clin Psychiatry. 2010 Dec;71(12):1629-35
pubmed: 20584514
N Engl J Med. 2019 Apr 4;380(14):1316-1325
pubmed: 30907987
Eur J Endocrinol. 2001 Nov;145(5):579-84
pubmed: 11720875
J Occup Environ Med. 2014 Mar;56(3):331-7
pubmed: 24561507
Obstet Gynecol. 2013 Jan;121(1):210-2
pubmed: 23262962
Assessment. 2006 Mar;13(1):27-45
pubmed: 16443717
JAMA. 2019 Aug 20;322(7):632-641
pubmed: 31429897
J Psychosom Res. 2018 Apr;107:14-19
pubmed: 29502758
J Affect Disord. 2019 Apr 1;248:139-146
pubmed: 30731281
Am J Obstet Gynecol. 2010 Jul;203(1):34.e1-8
pubmed: 20417475
J Clin Endocrinol Metab. 2004 Mar;89(3):1181-7
pubmed: 15001606
Arch Womens Ment Health. 2017 Aug;20(4):539-546
pubmed: 28593361
Nat Rev Endocrinol. 2017 Oct;13(10):610-622
pubmed: 28776582
Acta Psychiatr Scand Suppl. 2003;(418):51-6
pubmed: 12956815
J Pers Assess. 2007 Apr;88(2):187-204
pubmed: 17437384
J Clin Endocrinol Metab. 2017 Jan 1;102(1):69-77
pubmed: 27754809
Arch Womens Ment Health. 2019 Aug;22(4):475-483
pubmed: 30171361
Lancet Diabetes Endocrinol. 2020 Jun;8(6):501-510
pubmed: 32445737
World J Biol Psychiatry. 2009;10(4):324-9
pubmed: 19921974
N Engl J Med. 2017 Mar 2;376(9):815-825
pubmed: 28249134
Neuroscience. 2017 Feb 7;342:68-100
pubmed: 26434624
J Obstet Gynaecol Can. 2009 Sep;31(9):803-807
pubmed: 19941704
J Clin Endocrinol Metab. 2018 Aug 1;103(8):2889-2900
pubmed: 29846629
Women Birth. 2015 Sep;28(3):179-93
pubmed: 25765470
Pers Soc Psychol Bull. 2011 Oct;37(10):1362-75
pubmed: 21670220
Thyroid. 2017 Mar;27(3):315-389
pubmed: 28056690