Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
27 10 2020
27 10 2020
Historique:
received:
06
06
2019
accepted:
24
09
2020
entrez:
28
10
2020
pubmed:
29
10
2020
medline:
20
11
2020
Statut:
epublish
Résumé
Biomarkers are needed for predicting the effectiveness of disease modifying antirheumatic drugs (DMARDs). Here, using functional lipid mediator profiling and deeply phenotyped patients with early rheumatoid arthritis (RA), we observe that peripheral blood specialized pro-resolving mediator (SPM) concentrations are linked with both DMARD responsiveness and disease pathotype. Machine learning analysis demonstrates that baseline plasma concentrations of resolvin D4, 10S, 17S-dihydroxy-docosapentaenoic acid, 15R-Lipoxin (LX)A
Identifiants
pubmed: 33110080
doi: 10.1038/s41467-020-19176-z
pii: 10.1038/s41467-020-19176-z
pmc: PMC7591509
doi:
Substances chimiques
Antirheumatic Agents
0
Fatty Acids, Unsaturated
0
Lipoxins
0
resolvin D4
0
Docosahexaenoic Acids
25167-62-8
docosapentaenoic acid
NS3OZT14QT
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5420Subventions
Organisme : Wellcome Trust
ID : 107612/Z/15/Z
Pays : United Kingdom
Organisme : Arthritis Research UK
ID : 20022
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0800648
Pays : United Kingdom
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