Efavirenz induces DNA damage response pathway in lung cancer.
DNA damage response pathway
cell cycle
differential gene expression
efavirenz
lung cancer
Journal
Oncotarget
ISSN: 1949-2553
Titre abrégé: Oncotarget
Pays: United States
ID NLM: 101532965
Informations de publication
Date de publication:
13 Oct 2020
13 Oct 2020
Historique:
received:
14
04
2020
accepted:
16
07
2020
entrez:
28
10
2020
pubmed:
29
10
2020
medline:
29
10
2020
Statut:
epublish
Résumé
The cell-cycle related genes are potential gene targets in understanding the effects of efavirenz (EFV) in lung cancer. The present study aimed at investigating the expression changes of cell-cycle related genes in response to EFV drug treatment in human non-small cell lung carcinoma (A549) and normal lung fibroblast (MRC-5) cells. The loss in nuclear integrity in response to EFV was detected by 4', 6-diamidino-2-phenylindole (DAPI) staining. Gene expression profiling was performed using human cell cycle PathwayFinder RT
Identifiants
pubmed: 33110481
doi: 10.18632/oncotarget.27725
pii: 27725
pmc: PMC7566803
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3737-3748Déclaration de conflit d'intérêts
CONFLICTS OF INTEREST Authors have no conflicts of interest to declare.
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