AlphaB-crystallin and breast cancer: role and possible therapeutic strategies.
Apoptosis
Cancer
Heat shock protein
Therapeutic strategies
Journal
Cell stress & chaperones
ISSN: 1466-1268
Titre abrégé: Cell Stress Chaperones
Pays: Netherlands
ID NLM: 9610925
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
06
08
2020
accepted:
20
10
2020
revised:
10
10
2020
pubmed:
29
10
2020
medline:
25
12
2021
entrez:
28
10
2020
Statut:
ppublish
Résumé
AlphaB-crystallin (HSPB5) is one of the most prominent and well-studied members of the small heat shock protein (sHsp) family. To date, it is known that this protein modulates significant cellular processes and therefore, it is not surprising that its deregulation is involved in various human pathologies, including cancer diseases. Despite the pathogenic significance of HSPB5 in cancer and its regulatory mechanism related to aggressiveness is poorly understood, several reports describe the association of breast carcinoma progression with HSPB5, whose expression is also considered an independent predictor of breast cancer metastasis to the brain. Indeed, numerous authors indicate HSPB5 as a new valuable biomarker for clinicopathological parameters and poor prognosis in breast cancer. Considering the cytoprotective, anti-apoptotic, pro-angiogenic, and pro-metastatic properties of the sHsps, it is not surprising that they are considered as promising targets for anticancer treatment, even though, at present, a deeper understanding of their mode of action is needed to allow the development of precise therapeutic interventions. Data on the direct inhibition of different sHsps demonstrate promising results in cancer pathologies; however, specific strategies against HSPB5 have not been considered. This review highlights the most relevant findings on HSPB5 and its role in breast cancer, as well as the possible strategies in using HSPB5 inhibition for therapeutic purposes.
Identifiants
pubmed: 33111264
doi: 10.1007/s12192-020-01175-0
pii: 10.1007/s12192-020-01175-0
pmc: PMC7736448
doi:
Substances chimiques
Antineoplastic Agents
0
CRYAB protein, human
0
alpha-Crystallin B Chain
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
19-28Références
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