N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.
COVID-19
/ metabolism
Cells, Cultured
Coronavirus 3C Proteases
/ metabolism
Coronavirus NL63, Human
/ enzymology
Endothelial Cells
/ metabolism
Epithelial Cells
/ metabolism
Eukaryotic Initiation Factor-4G
/ metabolism
Host-Pathogen Interactions
Humans
Lung
/ metabolism
Peptide Fragments
/ analysis
Severe acute respiratory syndrome-related coronavirus
/ enzymology
SARS-CoV-2
/ enzymology
Substrate Specificity
Viral Proteins
/ metabolism
Covid19
LC-MS
isobaric labeling
protease substrates
terminomics
Journal
Proteomics
ISSN: 1615-9861
Titre abrégé: Proteomics
Pays: Germany
ID NLM: 101092707
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
25
09
2020
revised:
21
10
2020
pubmed:
29
10
2020
medline:
20
1
2021
entrez:
28
10
2020
Statut:
ppublish
Résumé
The genome of coronaviruses, including SARS-CoV-2, encodes for two proteases, a papain like (PL
Identifiants
pubmed: 33111431
doi: 10.1002/pmic.202000246
pmc: PMC7645863
doi:
Substances chimiques
EIF4G1 protein, human
0
Eukaryotic Initiation Factor-4G
0
Peptide Fragments
0
Viral Proteins
0
Coronavirus 3C Proteases
EC 3.4.22.28
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2000246Subventions
Organisme : Bundesministerium für Forschung und Technologie
ID : 05K18FLA
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
ID : Precision Medicine Inflammation - RTF-V
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB877-Z2
Pays : International
Informations de copyright
© 2020 The Authors. Proteomics published by Wiley-VCH GmbH.
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