Sensitive ELISA-based detection method for the mitophagy marker p-S65-Ub in human cells, autopsy brain, and blood samples.
Alzheimer disease
PINK1
PRKN
Parkin
Parkinson disease
autophagy
mitophagy
ubiquitin
Journal
Autophagy
ISSN: 1554-8635
Titre abrégé: Autophagy
Pays: United States
ID NLM: 101265188
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
pubmed:
29
10
2020
medline:
8
4
2022
entrez:
28
10
2020
Statut:
ppublish
Résumé
Mitochondrial dysfunction is an early, imminent event in neurodegenerative disorders including Parkinson disease (PD) and Alzheimer disease (AD). The enzymatic pair PINK1 and PRKN/Parkin recognize and transiently label damaged mitochondria with ubiquitin (Ub) phosphorylated at Ser65 (p-S65-Ub) as a signal for degradation via the autophagy-lysosome system (mitophagy). Despite its discovery in cell culture several years ago, robust and quantitative detection of altered mitophagy
Identifiants
pubmed: 33112198
doi: 10.1080/15548627.2020.1834712
pmc: PMC8496550
doi:
Substances chimiques
Ubiquitin
0
Ubiquitin-Protein Ligases
EC 2.3.2.27
Protein Kinases
EC 2.7.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
2613-2628Subventions
Organisme : NINDS NIH HHS
ID : U01 NS100603
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005134
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS082157
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG062677
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG062556
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS110085
Pays : United States
Organisme : NINDS NIH HHS
ID : U54 NS110435
Pays : United States
Organisme : NINDS NIH HHS
ID : RF1 NS085070
Pays : United States
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