Serum micro-RNA Identifies Early Stage Colorectal Cancer in a Multi-Ethnic Population.
Diagnosis
colorectal cancer
micro-RNA
multi-ethnic
Journal
Asian Pacific journal of cancer prevention : APJCP
ISSN: 2476-762X
Titre abrégé: Asian Pac J Cancer Prev
Pays: Thailand
ID NLM: 101130625
Informations de publication
Date de publication:
01 Oct 2020
01 Oct 2020
Historique:
received:
10
05
2020
entrez:
28
10
2020
pubmed:
29
10
2020
medline:
3
7
2021
Statut:
epublish
Résumé
Certain microRNAs (miR) have been previously described to be dysregulated in cancers and can be detected in blood samples. Studies examining the utility of miRs for colon cancer screening have primarily been performed in ethnically homogeneous groups of patients, thus the performance of miRs in multiethnic populations is unknown. Four miRs were selected that were shown to be aberrantly expressed in the blood or stool of patients with colorectal cancer (CRC) of various ethnicities. In this study, the ability of these miRs to discern early stage CRC was determined in a previously untested multiethnic population of 73 CRC cases and 18 controls. The ratios of non-vesicular to extracellular vesicular levels of miR's -21, -29a, and -92a were statistically and quantitatively related to CRC stage compared to controls. Serum levels of miR-21, miR-29a and miR-92a were able to significantly detect early stage CRC in a multiethnic and previously untested population.<br />.
Identifiants
pubmed: 33112562
doi: 10.31557/APJCP.2020.21.10.3019
pmc: PMC7798181
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
MIRN21 microRNA, human
0
MIRN29a microRNA, human
0
MIRN92 microRNA, human
0
MicroRNAs
0
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
3019-3026Subventions
Organisme : NCI NIH HHS
ID : P30 CA071789
Pays : United States
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