Sex Differences in the Longitudinal Course and Outcome of Bipolar Disorder in Youth.
Adolescent
Adult
Age of Onset
Anxiety Disorders
/ epidemiology
Attention Deficit Disorder with Hyperactivity
/ epidemiology
Bipolar Disorder
/ epidemiology
Child
Disease Progression
Female
Humans
Longitudinal Studies
Male
Self-Injurious Behavior
/ epidemiology
Sex Factors
Substance-Related Disorders
/ epidemiology
Young Adult
Journal
The Journal of clinical psychiatry
ISSN: 1555-2101
Titre abrégé: J Clin Psychiatry
Pays: United States
ID NLM: 7801243
Informations de publication
Date de publication:
27 10 2020
27 10 2020
Historique:
received:
08
11
2019
accepted:
15
05
2020
entrez:
28
10
2020
pubmed:
29
10
2020
medline:
29
12
2020
Statut:
epublish
Résumé
Despite substantial literature on sex differences in adults with bipolar disorder (BD), little is known about this topic in youth; this study examines sex differences in mood symptomatology and psychiatric comorbidity in prospectively followed youth with BD. A subsample of the Course and Outcome of Bipolar Youth study (N = 370; female n = 199, male n = 171) enrolled October 2000-July 2006 (age at intake = 7-17.11 years) who met DSM-IV criteria for bipolar I disorder (BD-I; n = 221), bipolar II disorder (BD-II; n = 26), or operationalized BD not otherwise specified (BD-NOS; n = 123) with ≥ 4 years follow-up was included. Analyses examined sex differences at intake and, prospectively, in mood symptomatology and psychiatric comorbidity for a mean ± SD follow-up of 10.5 ± 1.72 years. Females were older than males at intake (mean ± SD age = 13.33 ± 3.32 vs 12.04 ± 3.16 years; P = .0002) and at age at mood onset (9.33 ± 4.22 vs 7.53 ± 3.74 years; P < .0001). After adjustment for confounders, males spent more time with syndromal ADHD (Padjusted = .001) and females spent more time with syndromal anxiety (Padjusted = .02). There were trends toward males spending more time with substance use disorder and females having more non-suicidal self-injurious behavior (Padjusted = .07 and .09, respectively). There were no sex differences on outcome variables, including rate of or time to recovery and recurrence. Contrasting with adult literature, this study identified minimal sex differences in the course of youth with BD. Longer-term studies are needed to clarify if youth-onset BD remains a "sex neutral" subtype of BD or diverges according to sex in adulthood.
Identifiants
pubmed: 33113597
doi: 10.4088/JCP.19m13159
pmc: PMC8597235
mid: NIHMS1751813
doi:
pii:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIMH NIH HHS
ID : R01 MH059691
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH059929
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH059977
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH112544
Pays : United States
Informations de copyright
© Copyright 2020 Physicians Postgraduate Press, Inc.
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