Complement System: Promoter or Suppressor of Cancer Progression?
anaphylatoxins
cancer
complement system
immune infiltrate
tumor growth
tumor microenvironment
Journal
Antibodies (Basel, Switzerland)
ISSN: 2073-4468
Titre abrégé: Antibodies (Basel)
Pays: Switzerland
ID NLM: 101587489
Informations de publication
Date de publication:
25 Oct 2020
25 Oct 2020
Historique:
received:
13
08
2020
revised:
10
10
2020
accepted:
20
10
2020
entrez:
29
10
2020
pubmed:
30
10
2020
medline:
30
10
2020
Statut:
epublish
Résumé
Constituent of innate immunity, complement is present in the tumor microenvironment. The functions of complement include clearance of pathogens and maintenance of homeostasis, and as such could contribute to an anti-tumoral role in the context of certain cancers. However, multiple lines of evidence show that in many cancers, complement has pro-tumoral actions. The large number of complement molecules (over 30), the diversity of their functions (related or not to the complement cascade), and the variety of cancer types make the complement-cancer topic a very complex matter that has just started to be unraveled. With this review we highlight the context-dependent role of complement in cancer. Recent studies revealed that depending of the cancer type, complement can be pro or anti-tumoral and, even for the same type of cancer, different models presented opposite effects. We aim to clarify the current knowledge of the role of complement in human cancers and the insights from mouse models. Using our classification of human cancers based on the prognostic impact of the overexpression of complement genes, we emphasize the strong potential for therapeutic targeting the complement system in selected subgroups of cancer patients.
Identifiants
pubmed: 33113844
pii: antib9040057
doi: 10.3390/antib9040057
pmc: PMC7709131
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
FASEB J. 2019 Oct;33(10):11060-11071
pubmed: 31298935
Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11900-11905
pubmed: 31147461
Cancer Immunol Res. 2019 Feb;7(2):193-207
pubmed: 30514794
Trends Immunol. 2004 Jul;25(7):368-73
pubmed: 15207504
Front Immunol. 2019 Jul 19;10:1574
pubmed: 31379815
Ann Neurol. 2015 Jun;77(6):1007-26
pubmed: 25727254
J Invest Dermatol. 2014 Feb;134(2):498-506
pubmed: 23938460
J Immunol. 2016 Jun 1;196(11):4783-92
pubmed: 27183625
Nat Commun. 2018 Oct 10;9(1):4186
pubmed: 30305631
F1000Res. 2020 Feb 26;9:
pubmed: 32148776
Haematologica. 2019 Sep;104(9):1841-1852
pubmed: 30792198
Blood. 1998 Sep 15;92(6):1927-32
pubmed: 9731049
Scand J Immunol. 2020 Feb;91(2):e12830
pubmed: 31823416
Immunol Lett. 2015 Oct;167(2):67-71
pubmed: 26261870
Immunol Rev. 2016 Nov;274(1):33-58
pubmed: 27782325
JCI Insight. 2018 Jun 21;3(12):
pubmed: 29925688
Med Oncol. 2010 Sep;27(3):743-6
pubmed: 19662541
Front Immunol. 2015 May 26;6:257
pubmed: 26074922
Hum Pathol. 1996 Dec;27(12):1329-35
pubmed: 8958307
Mol Clin Oncol. 2018 Feb;8(2):315-319
pubmed: 29435296
Oncoimmunology. 2016 Nov 8;5(12):e1253653
pubmed: 28123895
J Oral Pathol Med. 2006 Oct;35(9):560-7
pubmed: 16968237
J Immunol. 2007 May 1;178(9):5991-8
pubmed: 17442984
Cell Death Dis. 2018 Feb 2;9(2):150
pubmed: 29396434
Clin Chem. 2005 May;51(5):856-63
pubmed: 15774575
Immunol Res. 2011 Oct;51(1):45-60
pubmed: 21850539
J Immunol. 2012 Nov 1;189(9):4674-83
pubmed: 23028051
Cancer Res. 2004 Sep 1;64(17):6310-8
pubmed: 15342420
Breast Cancer Res. 2014 Jun 16;16(3):R63
pubmed: 24935269
PLoS One. 2009 Jun 01;4(6):e5755
pubmed: 19484134
Annu Rev Immunol. 2010;28:131-55
pubmed: 19947883
Nat Rev Nephrol. 2018 Jan;14(1):26-47
pubmed: 29199277
Am J Pathol. 2017 May;187(5):1186-1197
pubmed: 28322200
Nat Immunol. 2017 Aug;18(8):889-898
pubmed: 28604720
Nature. 2020 Jan;577(7791):556-560
pubmed: 31942077
Science. 2014 Mar 14;343(6176):1260-3
pubmed: 24626930
Theranostics. 2020 Jul 9;10(19):8619-8632
pubmed: 32754267
Immunol Rev. 2016 Mar;270(1):95-112
pubmed: 26864107
Cancer Epidemiol Biomarkers Prev. 2010 Oct;19(10):2665-72
pubmed: 20802023
Cell Rep. 2014 Mar 27;6(6):1085-1095
pubmed: 24613353
Leukemia. 2015 Jan;29(1):107-14
pubmed: 24787488
J Occup Med Toxicol. 2019 Mar 15;14:9
pubmed: 30923558
Cell. 2015 Feb 12;160(4):700-714
pubmed: 25679762
Oncoimmunology. 2013 Sep 1;2(9):e26137
pubmed: 24228231
Aging (Albany NY). 2020 Apr 28;12(8):7585-7602
pubmed: 32345771
Cancer Res. 2014 Jul 1;74(13):3454-65
pubmed: 24786787
Nat Commun. 2016 Feb 01;7:10346
pubmed: 26831747
Semin Cell Dev Biol. 2019 Jan;85:153-163
pubmed: 29155219
J Natl Cancer Inst. 2013 Sep 18;105(18):1385-93
pubmed: 23940286
Adv Exp Med Biol. 2014;772:229-62
pubmed: 24272362
J Biol Chem. 2004 Nov 26;279(48):50321-8
pubmed: 15375167
Cell Rep. 2020 May 19;31(7):107628
pubmed: 32433953
Oncol Lett. 2013 Jul;6(1):43-48
pubmed: 23946775
Scand J Gastroenterol. 2004 Jul;39(7):674-9
pubmed: 15370690
Cancer Immunol Res. 2014 Mar;2(3):200-6
pubmed: 24778316
Tuberk Toraks. 2004;52(1):19-23
pubmed: 15143368
Nat Rev Clin Oncol. 2017 Dec;14(12):717-734
pubmed: 28741618
Oncoimmunology. 2017 Jul 13;6(10):e1349587
pubmed: 29123963
Nat Immunol. 2008 Nov;9(11):1225-35
pubmed: 18820683
J Invest Dermatol. 2020 Jul 16;:
pubmed: 32682912
J Immunol. 2009 Jul 1;183(1):749-58
pubmed: 19535640
Front Immunol. 2015 Jun 02;6:262
pubmed: 26082779
J Neuroimmunol. 2015 Jan 15;278:271-6
pubmed: 25468776
Cell. 2020 Mar 19;180(6):1081-1097.e24
pubmed: 32142650
Arch Pathol Lab Med. 2014 Jul;138(7):910-9
pubmed: 24978917
J Immunol. 2016 Sep 1;197(5):1762-75
pubmed: 27474078
Cancer Immunol Res. 2019 Jul;7(7):1091-1105
pubmed: 31164356
Cancer Cell Int. 2019 Nov 15;19:300
pubmed: 31787848
Urol Int. 2000;65(4):181-4
pubmed: 11112865
Mol Immunol. 2017 Sep;89:2-9
pubmed: 28601357
Immunol Rev. 2016 Nov;274(1):74-97
pubmed: 27782323
Immunol Rev. 2020 May;295(1):68-81
pubmed: 32166778
Cancer Lett. 2018 Jan 1;412:30-36
pubmed: 29031586
Pathol Oncol Res. 2016 Jan;22(1):169-77
pubmed: 26463353
Semin Nephrol. 2013 Nov;33(6):479-92
pubmed: 24161035
Semin Immunol. 2016 Jun;28(3):309-16
pubmed: 27009480
J Proteomics. 2011 Nov 18;74(12):2948-58
pubmed: 21840429
J Proteomics. 2014 Jan 16;96:1-12
pubmed: 24200836
Cancer Discov. 2017 Jul;7(7):694-703
pubmed: 28288993
J Ovarian Res. 2018 Nov 19;11(1):94
pubmed: 30453999
Immunity. 2015 Apr 21;42(4):767-77
pubmed: 25888260
J Immunol. 2015 Jun 1;194(11):5129-38
pubmed: 25917093
Clin Chim Acta. 2007 Feb;377(1-2):119-26
pubmed: 17067565
Nature. 2016 Feb 11;530(7589):177-83
pubmed: 26814963
Mol Immunol. 2015 Sep;67(1):43-50
pubmed: 25804937
J Biol Chem. 2015 Apr 24;290(17):10667-76
pubmed: 25739439
Leuk Res. 2008 Dec;32(12):1849-56
pubmed: 18584865
BMC Cancer. 2010 Oct 22;10:576
pubmed: 20969748
J Invest Dermatol. 2015 Feb;135(2):579-588
pubmed: 25184960
Nat Rev Cancer. 2012 Mar 15;12(4):298-306
pubmed: 22419253
J Immunol. 2012 Sep 15;189(6):2985-94
pubmed: 22914051
Immunol Res. 2013 May;56(1):109-21
pubmed: 23247987
Nat Rev Cancer. 2019 Dec;19(12):698-715
pubmed: 31666715
Oncotarget. 2016 Dec 27;7(52):86536-86546
pubmed: 27852032
Immunobiology. 2016 Oct;221(10):1037-45
pubmed: 27371361
PLoS One. 2015 Mar 23;10(3):e0119878
pubmed: 25799154
Front Immunol. 2016 Dec 21;7:599
pubmed: 28066412
Science. 2018 Feb 16;359(6377):794-797
pubmed: 29449492
Eur J Immunol. 2006 Apr;36(4):977-84
pubmed: 16525993
Onco Targets Ther. 2020 Feb 18;13:1497-1505
pubmed: 32110047
BMC Cancer. 2019 Mar 6;19(1):201
pubmed: 30841875
N Engl J Med. 2015 Jul 9;373(2):123-35
pubmed: 26028407
Mol Immunol. 2020 Aug;124:200-210
pubmed: 32599335
J Clin Invest. 2020 Aug 3;130(8):4039-4054
pubmed: 32369457
Int J Oncol. 2004 Jan;24(1):97-105
pubmed: 14654946
Sci Rep. 2019 Aug 19;9(1):12031
pubmed: 31427700
Oncotarget. 2017 Dec 26;9(5):6346-6355
pubmed: 29464077
Oncol Rep. 2014 Dec;32(6):2817-23
pubmed: 25230890
Clin Cancer Res. 2013 Apr 15;19(8):2004-13
pubmed: 23287562
Inflamm Res. 2010 Aug;59(8):659-66
pubmed: 20217457
J Clin Invest. 2017 Mar 1;127(3):780-789
pubmed: 28248200
Neoplasia. 2012 Nov;14(11):994-1004
pubmed: 23226093
Cancer Immunol Immunother. 2014 Nov;63(11):1129-40
pubmed: 25038892
Med Sci Monit. 2018 Mar 17;24:1581-1587
pubmed: 29549708
Zhonghua Yi Xue Za Zhi. 2014 Jul 22;94(28):2175-9
pubmed: 25331466
Am J Respir Crit Care Med. 2018 May 1;197(9):1164-1176
pubmed: 29327939
Nat Med. 2003 Jun;9(6):653-60
pubmed: 12778163
Cancer Res. 2018 Jan 1;78(1):143-156
pubmed: 29118090