Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae Alkaloids.
Amaryllidaceae alkaloids
anti-cholinesterase
antiparasitic
antitumor
antiviral
biosynthesis
specialized metabolism
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
23 Oct 2020
23 Oct 2020
Historique:
received:
04
08
2020
revised:
07
10
2020
accepted:
21
10
2020
entrez:
29
10
2020
pubmed:
30
10
2020
medline:
1
4
2021
Statut:
epublish
Résumé
Alkaloids are an important group of specialized nitrogen metabolites with a wide range of biochemical and pharmacological effects. Since the first publication on lycorine in 1877, more than 650 alkaloids have been extracted from Amaryllidaceae bulbous plants and clustered together as the Amaryllidaceae alkaloids (AAs) family. AAs are specifically remarkable for their diverse pharmaceutical properties, as exemplified by the success of galantamine used to treat the symptoms of Alzheimer's disease. This review addresses the isolation, biological, and structure activity of AAs discovered from January 2015 to August 2020, supporting their therapeutic interest.
Identifiants
pubmed: 33113950
pii: molecules25214901
doi: 10.3390/molecules25214901
pmc: PMC7660210
pii:
doi:
Substances chimiques
Amaryllidaceae Alkaloids
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Canada Research Chairs
ID : 950-232164
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