Assessment of the Theranostic Potential of Gold Nanostars-A Multimodal Imaging and Photothermal Treatment Study.
cancer
computed tomography
gold nanostars
nanoparticles
photoacoustic imaging
photothermal therapy
theranostic agents
Journal
Nanomaterials (Basel, Switzerland)
ISSN: 2079-4991
Titre abrégé: Nanomaterials (Basel)
Pays: Switzerland
ID NLM: 101610216
Informations de publication
Date de publication:
23 Oct 2020
23 Oct 2020
Historique:
received:
31
08
2020
revised:
19
10
2020
accepted:
21
10
2020
entrez:
29
10
2020
pubmed:
30
10
2020
medline:
30
10
2020
Statut:
epublish
Résumé
Gold nanoparticles offer the possibility to combine both imaging and therapy of otherwise difficult to treat tumors. To validate and further improve their potential, we describe the use of gold nanostars that were functionalized with a polyethyleneglycol-maleimide coating for in vitro and in vivo photoacoustic imaging (PAI), computed tomography (CT), as well as photothermal therapy (PTT) of cancer cells and tumor masses, respectively. Nanostar shaped particles show a high absorption coefficient in the near infrared region and have a hydrodynamic size in biological medium around 100 nm, which allows optimal intra-tumoral retention. Using these nanostars for in vitro labeling of tumor cells, high intracellular nanostar concentrations could be achieved, resulting in high PAI and CT contrast and effective PTT. By injecting the nanostars intratumorally, high contrast could be generated in vivo using PAI and CT, which allowed successful multi-modal tumor imaging. PTT was successfully induced, resulting in tumor cell death and subsequent inhibition of tumor growth. Therefore, gold nanostars are versatile theranostic agents for tumor therapy.
Identifiants
pubmed: 33114177
pii: nano10112112
doi: 10.3390/nano10112112
pmc: PMC7690792
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Agentschap voor Innovatie door Wetenschap en Technologie
ID : 080017
Organisme : Agentschap voor Innovatie door Wetenschap en Technologie
ID : SBO 140061 (NanoCoMIT)
Organisme : Onderzoeksraad, KU Leuven
ID : PF IMIR (10/017)
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