Statins Stimulate New Myocyte Formation After Myocardial Infarction by Activating Growth and Differentiation of the Endogenous Cardiac Stem Cells.
Animals
Cell Differentiation
/ drug effects
Cell Proliferation
/ drug effects
Cells, Cultured
Disease Models, Animal
Female
Hydroxymethylglutaryl-CoA Reductase Inhibitors
/ administration & dosage
Mice
Muscle Cells
/ cytology
Myocardial Infarction
/ drug therapy
Myocardium
/ cytology
Phosphorylation
/ drug effects
Pravastatin
/ administration & dosage
Proto-Oncogene Proteins c-akt
/ metabolism
Rats
Rosuvastatin Calcium
/ administration & dosage
Simvastatin
/ administration & dosage
Stem Cells
/ cytology
3-hydroxy-3-methylglutaryl coenzyme A
Akt
Statins
cardiac stem cells
myocardial regeneration
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
26 Oct 2020
26 Oct 2020
Historique:
received:
25
09
2020
revised:
21
10
2020
accepted:
22
10
2020
entrez:
29
10
2020
pubmed:
30
10
2020
medline:
4
3
2021
Statut:
epublish
Résumé
The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) exert pleiotropic effects on cardiac cell biology which are not yet fully understood. Here we tested whether statin treatment affects resident endogenous cardiac stem/progenitor cell (CSC) activation in vitro and in vivo after myocardial infarction (MI). Statins (Rosuvastatin, Simvastatin and Pravastatin) significantly increased CSC expansion in vitro as measured by both BrdU incorporation and cell growth curve. Additionally, statins increased CSC clonal expansion and cardiosphere formation. The effects of statins on CSC growth and differentiation depended on Akt phosphorylation. Twenty-eight days after myocardial infarction by permanent coronary ligation in rats, the number of endogenous CSCs in the infarct border zone was significantly increased by Rosuvastatin-treatment as compared to untreated controls. Additionally, commitment of the activated CSCs into the myogenic lineage (c-kit
Identifiants
pubmed: 33114544
pii: ijms21217927
doi: 10.3390/ijms21217927
pmc: PMC7663580
pii:
doi:
Substances chimiques
Hydroxymethylglutaryl-CoA Reductase Inhibitors
0
Rosuvastatin Calcium
83MVU38M7Q
Simvastatin
AGG2FN16EV
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Pravastatin
KXO2KT9N0G
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : PRIN2015 2015ZTT5KB_004
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : 2017NKB2N4_005
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : PON03PE00009_2-iCARE
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : POR Prodotti Alimentari
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