Mohawk is a transcription factor that promotes meniscus cell phenotype and tissue repair and reduces osteoarthritis severity.
Journal
Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086
Informations de publication
Date de publication:
28 10 2020
28 10 2020
Historique:
received:
14
02
2019
revised:
06
02
2020
accepted:
21
09
2020
entrez:
29
10
2020
pubmed:
30
10
2020
medline:
24
6
2021
Statut:
ppublish
Résumé
Meniscus tears are common knee injuries and a major osteoarthritis (OA) risk factor. Knowledge gaps that limit the development of therapies for meniscus injury and degeneration concern transcription factors that control the meniscus cell phenotype. Analysis of RNA sequencing data from 37 human tissues in the Genotype-Tissue Expression database and RNA sequencing data from meniscus and articular cartilage showed that transcription factor Mohawk (MKX) is highly enriched in meniscus. In human meniscus cells, MKX regulates the expression of meniscus marker genes, OA-related genes, and other transcription factors, including Scleraxis (
Identifiants
pubmed: 33115953
pii: 12/567/eaan7967
doi: 10.1126/scitranslmed.aan7967
pmc: PMC7955769
mid: NIHMS1659893
pii:
doi:
Substances chimiques
Homeodomain Proteins
0
Mkx protein, human
0
Transcription Factors
0
mohawk protein, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIA NIH HHS
ID : P01 AG007996
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG049617
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR065379
Pays : United States
Organisme : NIA NIH HHS
ID : R37 AG059418
Pays : United States
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
Références
Am J Pathol. 2008 Oct;173(4):1085-99
pubmed: 18772333
Acta Biomater. 2012 Oct;8(10):3687-94
pubmed: 22698946
Am J Sports Med. 1993 Sep-Oct;21(5):672-9
pubmed: 8238706
Bioinformatics. 2015 Jan 15;31(2):166-9
pubmed: 25260700
Arthritis Rheumatol. 2015 May;67(8):2085-96
pubmed: 25940308
Tissue Eng. 2007 Sep;13(9):2227-37
pubmed: 17561802
Curr Opin Biotechnol. 1999 Oct;10(5):440-7
pubmed: 10508634
Tissue Eng Part A. 2010 Feb;16(2):523-33
pubmed: 19715387
Stem Cell Reports. 2014 Nov 11;3(5):789-803
pubmed: 25418724
J Orthop Res. 2014 Jan;32(1):46-53
pubmed: 24108661
Bioinformatics. 2006 Jul 1;22(13):1600-7
pubmed: 16606683
Osteoarthritis Cartilage. 2011 Sep;19(9):1132-41
pubmed: 21683797
Arthroscopy. 2010 Jul;26(7):936-48
pubmed: 20620793
J Am Acad Orthop Surg. 2013 Apr;21(4):204-13
pubmed: 23545726
Biomaterials. 2011 Oct;32(30):7411-31
pubmed: 21764438
J Biol Chem. 2011 Feb 18;286(7):5855-67
pubmed: 21173153
Connect Tissue Res. 2017 May - Jul;58(3-4):259-270
pubmed: 27925477
Arthritis Rheum. 2006 Oct;54(10):3254-66
pubmed: 17009260
Connect Tissue Res. 1998;39(4):233-44
pubmed: 11063004
Arthritis Rheum. 2013 Aug;65(8):2090-101
pubmed: 23658108
Nat Genet. 2013 Jun;45(6):580-5
pubmed: 23715323
Am J Sports Med. 1999 Mar-Apr;27(2):242-50
pubmed: 10102109
Cells Tissues Organs. 2010;192(3):158-66
pubmed: 20407224
Bioinformatics. 2010 Jan 1;26(1):139-40
pubmed: 19910308
Nat Commun. 2015 Dec 16;6:10195
pubmed: 26671628
Biomaterials. 2012 Oct;33(28):6709-20
pubmed: 22770570
Osteoarthritis Cartilage. 2016 Apr;24(4):709-18
pubmed: 26585241
Genome Biol. 2014 Feb 03;15(2):R29
pubmed: 24485249
Am J Sports Med. 2017 Mar;45(3):604-611
pubmed: 27895039
Arthritis Rheumatol. 2016 Aug;68(8):1876-86
pubmed: 26881698
J Orthop Surg Res. 2015 Mar 18;10:34
pubmed: 25889148
Biomaterials. 2007 Oct;28(29):4321-9
pubmed: 17610948
Pathol Res Pract. 2002;198(5):317-25
pubmed: 12092767
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Arthritis Rheum. 2013 Feb;65(2):418-28
pubmed: 23124445
Am J Sports Med. 2009 Jul;37(7):1434-43
pubmed: 19567666
J Clin Invest. 2010 Sep;120(9):3340-9
pubmed: 20679726
J Orthop Res. 2015 Jan;33(1):1-8
pubmed: 25312837
Osteoarthritis Cartilage. 2018 Nov;26(11):1531-1538
pubmed: 30081074
Tissue Eng Part A. 2016 Mar;22(5-6):436-48
pubmed: 26842062
Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2509-14
pubmed: 9482916
Genome Biol. 2016 May 06;17(1):91
pubmed: 27154141
Osteoarthritis Cartilage. 2007 Sep;15(9):1061-9
pubmed: 17470400
Osteoarthritis Cartilage. 2004 Sep;12(9):736-44
pubmed: 15325640
Curr Opin Rheumatol. 2012 Mar;24(2):152-7
pubmed: 22227878
Osteoarthritis Cartilage. 2010 Oct;18 Suppl 3:S17-23
pubmed: 20864019
J Gen Virol. 2000 Nov;81(Pt 11):2573-2604
pubmed: 11038369
Science. 2015 May 8;348(6235):648-60
pubmed: 25954001
Knee Surg Sports Traumatol Arthrosc. 1995;3(3):130-4
pubmed: 8821266
Acta Biomater. 2018 Aug;76:126-134
pubmed: 29908335
Clin Orthop Relat Res. 1999 Oct;(367 Suppl):S410-8
pubmed: 10546663
Sci Transl Med. 2014 Dec 10;6(266):266ra171
pubmed: 25504882
Osteoarthritis Cartilage. 2011 Oct;19(10):1246-53
pubmed: 21843649
Int Orthop. 2014 Sep;38(9):1761-9
pubmed: 25038968