PHF24 is expressed in the inhibitory interneurons in rats.

Animals Calbindin 2 / metabolism Calbindins / metabolism Central Nervous System / cytology Disease Models, Animal Gene Expression Genetic Association Studies Homeodomain Proteins / genetics Immunohistochemistry Interneurons / metabolism Intracellular Signaling Peptides and Proteins / genetics Olfactory Bulb / metabolism Rats, Inbred F344 Seizures / genetics Signal Transduction / genetics Spinal Cord / metabolism gamma-Aminobutyric Acid / metabolism
GABAB receptor PHF24 epilepsy inhibitory interneuron mutant rat

Journal

Experimental animals
ISSN: 1881-7122
Titre abrégé: Exp Anim
Pays: Japan
ID NLM: 9604830

Informations de publication

Date de publication:
06 Feb 2021
Historique:
pubmed: 30 10 2020
medline: 24 7 2021
entrez: 29 10 2020
Statut: ppublish

Résumé

Noda epileptic rat (NER) is a mutant model for epilepsy that exhibits spontaneous generalized tonic-clonic seizure. Epileptogenesis of NER remains to be elucidated; but it is detected an insertion of an endogenous retrovirus sequence in intron 2 of the PHD finger protein 24 (Phf24) gene, encoding Gαi-interacting protein (GINIP). Phf24 is a strong candidate gene for epileptogenesis in NER. PHF24 modulates GABA

Identifiants

DOI: 10.1538/expanim.20-0105 PMID: 33115988 PMC: PMC7887615
pubmed: 33115988
doi: 10.1538/expanim.20-0105
pmc: PMC7887615
doi:

Substances chimiques

Calbindin 2 0
Calbindins 0
GINIP protein, rat 0
Homeodomain Proteins 0
Intracellular Signaling Peptides and Proteins 0
PHF24 protein, human 0
gamma-Aminobutyric Acid 56-12-2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

137-143

Références

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Auteurs

Yuki Numakura (Y)

Laboratory of Veterinary Pathology, Osaka Prefecture University, 1-58 Ourai-kita, Izumisano, Osaka 598-8531, Japan.

Risa Uemura (R)

Laboratory of Veterinary Pathology, Osaka Prefecture University, 1-58 Ourai-kita, Izumisano, Osaka 598-8531, Japan.

Miyuu Tanaka (M)

Laboratory of Veterinary Pathology, Osaka Prefecture University, 1-58 Ourai-kita, Izumisano, Osaka 598-8531, Japan.

Takeshi Izawa (T)

Laboratory of Veterinary Pathology, Osaka Prefecture University, 1-58 Ourai-kita, Izumisano, Osaka 598-8531, Japan.

Jyoji Yamate (J)

Laboratory of Veterinary Pathology, Osaka Prefecture University, 1-58 Ourai-kita, Izumisano, Osaka 598-8531, Japan.

Takashi Kuramoto (T)

Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
Department of Animal Science, Faculty of Agriculture, Tokyo University of Agriculture, 1737 Funako, Atsugi, Kanagawa 243-0034, Japan.

Takehito Kaneko (T)

Laboratory of Animal Reproduction and Development, Graduate School of Science and Engineering, Iwate University, 4-35 Ueda, Morioka-shi, Iwate 020-8551, Japan.

Tomoji Mashimo (T)

Division of Animal Genetics, Laboratory Animal Research Center, Institute of Medical Science, the University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

Takashi Yamamoto (T)

Molecular Genetics Laboratory, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8526, Japan.

Tadao Serikawa (T)

Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.

Mitsuru Kuwamura (M)

Laboratory of Veterinary Pathology, Osaka Prefecture University, 1-58 Ourai-kita, Izumisano, Osaka 598-8531, Japan.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › PHF24 is expressed in the inhibitory...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Protéines de liaison au calcium › Calbindines › Calbindine-2 › PHF24 is expressed in the inhibitory...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Protéines de liaison au calcium › Calbindines › PHF24 is expressed in the inhibitory...
questionsmedicales.fr › Système nerveux › Système nerveux central › PHF24 is expressed in the inhibitory...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › PHF24 is expressed in the inhibitory...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › PHF24 is expressed in the inhibitory...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Études d'associations génétiques › PHF24 is expressed in the inhibitory...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Protéines à homéodomaine › PHF24 is expressed in the inhibitory...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Immunohistochimie › PHF24 is expressed in the inhibitory...
questionsmedicales.fr › Cellules › Neurones › Interneurones › PHF24 is expressed in the inhibitory...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › PHF24 is expressed in the inhibitory...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Bulbe olfactif › PHF24 is expressed in the inhibitory...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Lignées consanguines de rats › Rats de lignée F344 › PHF24 is expressed in the inhibitory...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Crises épileptiques › PHF24 is expressed in the inhibitory...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › PHF24 is expressed in the inhibitory...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › PHF24 is expressed in the inhibitory...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Amino-butyrates › Acide gamma-amino-butyrique › PHF24 is expressed in the inhibitory...