Tunable dynamics of B cell selection in gut germinal centres.
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
07
03
2020
accepted:
29
07
2020
pubmed:
30
10
2020
medline:
2
3
2021
entrez:
29
10
2020
Statut:
ppublish
Résumé
Germinal centres, the structures in which B cells evolve to produce antibodies with high affinity for various antigens, usually form transiently in lymphoid organs in response to infection or immunization. In lymphoid organs associated with the gut, however, germinal centres are chronically present. These gut-associated germinal centres can support targeted antibody responses to gut infections and immunization
Identifiants
pubmed: 33116306
doi: 10.1038/s41586-020-2865-9
pii: 10.1038/s41586-020-2865-9
pmc: PMC7726069
mid: NIHMS1616530
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
321-326Subventions
Organisme : NIAID NIH HHS
ID : R21 AI144827
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK093674
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI139117
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK113375
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK116646
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI119006
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : DP1 AI144248
Pays : United States
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