Ecotoxicity Evaluation of Pristine and Indolicidin-coated Silver Nanoparticles in Aquatic and Terrestrial Ecosystem.
Animals
Antimicrobial Cationic Peptides
/ chemical synthesis
Aquatic Organisms
/ drug effects
Crustacea
/ drug effects
Cucumis sativus
/ drug effects
Daphnia
/ cytology
Ecosystem
Ecotoxicology
Germination
/ drug effects
Lepidium
/ drug effects
Lactuca
/ drug effects
Metal Nanoparticles
/ toxicity
Seeds
/ drug effects
Silver
/ toxicity
Toxicity Tests
antimicrobial peptide indolicidin
in vivo toxicity
nanotoxicology
phytotoxicity
silver nanoparticles
Journal
International journal of nanomedicine
ISSN: 1178-2013
Titre abrégé: Int J Nanomedicine
Pays: New Zealand
ID NLM: 101263847
Informations de publication
Date de publication:
2020
2020
Historique:
received:
13
05
2020
accepted:
19
08
2020
entrez:
29
10
2020
pubmed:
30
10
2020
medline:
18
11
2020
Statut:
epublish
Résumé
Metallic nanoparticles (NPs) are highly exploited in manufacturing and medical processes in a broad spectrum of industrial applications and in the academic sectors. Several studies have suggested that many metallic nanomaterials including those derived by silver (Ag) are entering the ecosystem to cause significant toxic consequences in cell culture and animal models. However, ecotoxicity studies are still receiving limited attention when designing functionalized and non.-functionalized AgNPs. This study aimed to investigate different ecotoxicological profiles of AgNPs, which were analyzed in two different states: in pristine form uncoated AgNPs and coated AgNPs with the antimicrobial peptide indolicidin. These two types of AgNPs are exploited for a set of different tests using Ecotoxicological studies showed that the most sensitive organism to AgNPs was crustacean The obtained results demonstrate that high ecotoxicity induced by AgNPs is strongly dependent on the surface chemistry, thus the presence of the antimicrobial peptide. This finding opens new avenues to design and fabricate the next generation of metallic nanoparticles to ensure the biosafety and risk of using engineered nanoparticles in consumer products.
Sections du résumé
BACKGROUND
BACKGROUND
Metallic nanoparticles (NPs) are highly exploited in manufacturing and medical processes in a broad spectrum of industrial applications and in the academic sectors. Several studies have suggested that many metallic nanomaterials including those derived by silver (Ag) are entering the ecosystem to cause significant toxic consequences in cell culture and animal models. However, ecotoxicity studies are still receiving limited attention when designing functionalized and non.-functionalized AgNPs.
OBJECTIVE
OBJECTIVE
This study aimed to investigate different ecotoxicological profiles of AgNPs, which were analyzed in two different states: in pristine form uncoated AgNPs and coated AgNPs with the antimicrobial peptide indolicidin. These two types of AgNPs are exploited for a set of different tests using
RESULTS
RESULTS
Ecotoxicological studies showed that the most sensitive organism to AgNPs was crustacean
CONCLUSION
CONCLUSIONS
The obtained results demonstrate that high ecotoxicity induced by AgNPs is strongly dependent on the surface chemistry, thus the presence of the antimicrobial peptide. This finding opens new avenues to design and fabricate the next generation of metallic nanoparticles to ensure the biosafety and risk of using engineered nanoparticles in consumer products.
Identifiants
pubmed: 33116520
doi: 10.2147/IJN.S260396
pii: 260396
pmc: PMC7585781
doi:
Substances chimiques
Antimicrobial Cationic Peptides
0
indolicidin
073SBV429N
Silver
3M4G523W1G
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8097-8108Informations de copyright
© 2020 Falanga et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
Références
Environ Sci Technol. 2009 Aug 1;43(15):6046-51
pubmed: 19731716
Environ Toxicol Chem. 2010 Dec;29(12):2742-50
pubmed: 20890913
Trends Microbiol. 2019 Apr;27(4):323-338
pubmed: 30683453
Ecotoxicology. 2008 Jul;17(5):315-25
pubmed: 18408994
Crit Rev Microbiol. 2016;42(1):46-56
pubmed: 24754250
PLoS One. 2019 Apr 3;14(4):e0214398
pubmed: 30943225
Sci Total Environ. 2009 Feb 1;407(4):1461-8
pubmed: 19038417
ACS Nano. 2009 Oct 27;3(10):3221-7
pubmed: 19772305
Int J Nanomedicine. 2013;8:4303-14
pubmed: 24235828
Environ Toxicol Chem. 2008 Sep;27(9):1972-8
pubmed: 18690762
Nat Biotechnol. 2006 Dec;24(12):1551-7
pubmed: 17160061
Ecotoxicol Environ Saf. 2014 Sep 7;110:73-81
pubmed: 25199585
Environ Sci Technol. 2010 Oct 1;44(19):7699-704
pubmed: 20831153
Regul Toxicol Pharmacol. 2018 Oct;98:231-239
pubmed: 30096342
Anal Chem. 2013 Mar 19;85(6):3036-49
pubmed: 23427995
Aquat Toxicol. 2018 May;198:158-164
pubmed: 29547731
J Pharm Sci. 2014 Jul;103(7):1931-1944
pubmed: 24824033
Beilstein J Nanotechnol. 2019 Sep 2;10:1802-1817
pubmed: 31579097
Aquat Toxicol. 2011 Jan 17;101(1):117-25
pubmed: 20952077
Environ Monit Assess. 1990 Jan;14(1):45-58
pubmed: 24243256
Chemosphere. 2020 Nov;258:127346
pubmed: 32544815
Curr Opin Pharmacol. 2006 Oct;6(5):468-72
pubmed: 16890021
Environ Sci Technol. 2010 Dec 15;44(24):9571-7
pubmed: 21082828
J Environ Sci (China). 2018 Apr;66:138-145
pubmed: 29628080
Molecules. 2011 Oct 24;16(10):8894-918
pubmed: 22024958
J Nanobiotechnology. 2012 Apr 02;10:14
pubmed: 22472056
PLoS One. 2014 Jul 21;9(7):e102108
pubmed: 25048192
Antimicrob Agents Chemother. 2013 Nov;57(11):5665-73
pubmed: 24002100
Appl Microbiol Biotechnol. 2014 Mar;98(5):1951-61
pubmed: 24407450
Environ Sci Pollut Res Int. 2019 Jan;26(2):1537-1547
pubmed: 30430449
Curr Med Chem. 2015;22(14):1665-77
pubmed: 25760092
Bioresour Technol. 2011 Jan;102(2):1516-20
pubmed: 20797851
Recent Pat Antiinfect Drug Discov. 2006 Jun;1(2):201-7
pubmed: 18221145
Microbiol Mol Biol Rev. 2010 Sep;74(3):417-33
pubmed: 20805405
Water Res. 2006 Nov;40(19):3527-32
pubmed: 17011015
Nanoscale Res Lett. 2017 Dec;12(1):92
pubmed: 28168616
Environ Pollut. 2015 Aug;203:145-152
pubmed: 25884346
J Appl Microbiol. 2012 May;112(5):841-52
pubmed: 22324439
Environ Sci Pollut Res Int. 2019 Jan;26(3):2409-2420
pubmed: 30467754
Environ Pollut. 2017 May;224:597-605
pubmed: 28242252
Sci Total Environ. 2018 Apr 1;619-620:328-337
pubmed: 29154051
Toxicology. 2010 Mar 10;269(2-3):92-104
pubmed: 20105448
J Environ Monit. 2011 May;13(5):1227-35
pubmed: 21499624
Int J Nanomedicine. 2012;7:2767-81
pubmed: 22745541
Environ Pollut. 2019 Oct;253:578-598
pubmed: 31330350
Aquat Toxicol. 2016 Aug;177:526-35
pubmed: 27449283
Curr Eye Res. 2005 Jul;30(7):505-15
pubmed: 16020284
Environ Sci Pollut Res Int. 2019 Mar;26(8):7390-7404
pubmed: 30673947