Advances and Challenges in Understanding MicroRNA Function in Tauopathies: A Case Study of miR-132/212.
PS19
miR-132
microRNA
tau
tauopathies
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2020
2020
Historique:
received:
01
07
2020
accepted:
01
09
2020
entrez:
29
10
2020
pubmed:
30
10
2020
medline:
30
10
2020
Statut:
epublish
Résumé
In the past decade, several groups have reported that microRNAs (miRNAs) can participate in the regulation of tau protein at different levels, including its expression, alternative splicing, phosphorylation, and aggregation. These observations are significant, since the abnormal regulation and deposition of tau is associated with nearly 30 neurodegenerative disorders. Interestingly, miRNA profiles go awry in tauopathies such as Alzheimer's disease, progressive supranuclear palsy, and frontotemporal dementia. Understanding the role and impact of miRNAs on tau biology could therefore provide important insights into disease risk, diagnostics, and perhaps therapeutics. In this Perspective article, we discuss recent advances in miRNA research related to tau. While proof-of-principle studies hold promise, physiological validation remains limited. To help fill this gap, we describe herein a pure tauopathy mouse model deficient for the miR-132/212 cluster. This miRNA family is strongly downregulated in human tauopathies and shown to regulate tau
Identifiants
pubmed: 33117266
doi: 10.3389/fneur.2020.578720
pmc: PMC7553085
doi:
Types de publication
Journal Article
Langues
eng
Pagination
578720Informations de copyright
Copyright © 2020 Boscher, Hernandez-Rapp, Petry, Keraudren, Rainone, Loiselle, Goupil, Turgeon, St-Amour, Planel and Hébert.
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