Fetuin-A in Infants Born Small- or Large-for-Gestational-Age.
fetuin A
insulin
insulin-like growth factor
large-for-gestational-age
small-for-gestational-age
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2020
2020
Historique:
received:
31
05
2020
accepted:
02
09
2020
entrez:
29
10
2020
pubmed:
30
10
2020
medline:
22
5
2021
Statut:
epublish
Résumé
Fetuin-A is a multifunctional glycoprotein that has been implicated in insulin resistance and bone metabolism. We assessed whether fetuin-A is associated with poor or excessive fetal growth. In the Shanghai Birth Cohort, we conducted a nested case-control study of 60 trios of small-for-gestational-age (SGA, birth weight <10th percentile), optimal-for-gestational-age (OGA, 25-75th, the reference) and large-for-gestational-age (LGA, >90th percentile) infants matched by sex and gestational age. Cord plasma concentrations of fetuin-A and fetal growth factors [insulin, proinsulin, insulin-like growth factor (IGF)-I and IGF-II] were measured. Cord plasma fetuin-A concentrations were higher in SGA (809.4 ± 306.9 μg/ml,
Identifiants
pubmed: 33117283
doi: 10.3389/fendo.2020.567955
pmc: PMC7561389
doi:
Substances chimiques
AHSG protein, human
0
Biomarkers
0
alpha-2-HS-Glycoprotein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
567955Subventions
Organisme : CIHR
ID : 158616
Pays : Canada
Informations de copyright
Copyright © 2020 Wang, Wang, Yang, Dong, He, Fang, Huang, Yu, Zhang, Zhao, Zheng, Huang, Zhang, Ouyang and Luo.
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