Radiomic Features From Multi-Parameter MRI Combined With Clinical Parameters Predict Molecular Subgroups in Patients With Medulloblastoma.

machine learning medulloblastoma molecular subgroups prediction radiomics

Journal

Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867

Informations de publication

Date de publication:
2020
Historique:
received: 12 05 2020
accepted: 01 09 2020
entrez: 29 10 2020
pubmed: 30 10 2020
medline: 30 10 2020
Statut: epublish

Résumé

The 2016 WHO classification of central nervous system tumors has included four molecular subgroups under medulloblastoma (MB) as sonic hedgehog (SHH), wingless (WNT), Grade 3, and Group 4. We aimed to develop machine learning models for predicting MB molecular subgroups based on multi-parameter magnetic resonance imaging (MRI) radiomics, tumor locations, and clinical factors. A total of 122 MB patients were enrolled retrospectively. After selecting robust, non-redundant, and relevant features from 5,529 extracted radiomics features, a random forest model was constructed based on a training cohort (

Identifiants

pubmed: 33117690
doi: 10.3389/fonc.2020.558162
pmc: PMC7566191
doi:

Types de publication

Journal Article

Langues

eng

Pagination

558162

Informations de copyright

Copyright © 2020 Yan, Liu, Wang, Zhao, Li, Li, Wang, Yuan, Geng, Zhang, Liu, Duan, Zhan, Pei, Zhao, Sun, Sun, Wang, Hong, Wang, Guo, Li, Cheng, Liu, Ng, Li and Zhang.

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Auteurs

Jing Yan (J)

Department of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Lei Liu (L)

Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

Weiwei Wang (W)

Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Yuanshen Zhao (Y)

Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

Kay Ka-Wai Li (KK)

Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.

Ke Li (K)

Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Li Wang (L)

Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Binke Yuan (B)

Center for Language and Brain, Shenzhen Institute of Neuroscience, Shenzhen, China.

Haiyang Geng (H)

Shenzhen Key Laboratory of Affective and Social Neuroscience, Center for Brain Disorders and Cognitive Sciences, Shenzhen University, Shenzhen, China.
Department of Biomedical Sciences of Cells and Systems, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

Shenghai Zhang (S)

Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

Zhen Liu (Z)

Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Wenchao Duan (W)

Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Yunbo Zhan (Y)

Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Dongling Pei (D)

Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Haibiao Zhao (H)

Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Tao Sun (T)

Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Chen Sun (C)

Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Wenqing Wang (W)

Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Xuanke Hong (X)

Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Xiangxiang Wang (X)

Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Yu Guo (Y)

Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Wencai Li (W)

Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Jingliang Cheng (J)

Department of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Xianzhi Liu (X)

Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Ho-Keung Ng (HK)

Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.

Zhicheng Li (Z)

Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

Zhenyu Zhang (Z)

Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Classifications MeSH