Searching for the Mechanical Fingerprint of Pre-diabetes in T1DM: A Case Report Study.
AFM
biomechanics
cell mechanics
diabetes
pre-type 1 diabetes
red blood cells
standard linear solid model
viscoelasticity
Journal
Frontiers in bioengineering and biotechnology
ISSN: 2296-4185
Titre abrégé: Front Bioeng Biotechnol
Pays: Switzerland
ID NLM: 101632513
Informations de publication
Date de publication:
2020
2020
Historique:
received:
05
06
2020
accepted:
27
08
2020
entrez:
29
10
2020
pubmed:
30
10
2020
medline:
30
10
2020
Statut:
epublish
Résumé
We report the case of a 38 year-old Caucasian man enrolled in a study aimed at investigating the physical properties of red blood cells (RBCs) using advanced microscopy techniques, including Atomic Force Microscopy (AFM). At the time of his first enrolment in the study, he had normal Fasting Plasma Glucose (FPG) values, a BMI of 24.1, and no other symptoms of diabetes, including fatigue, high triglycerides, low HDL cholesterol, and altered inflammatory and corpuscular RBC indices. The subject reported no family history of diabetes, obesity, and cardiovascular diseases. Despite his apparently healthy conditions, the biomechanics of his RBCs was altered, showing increased values of stiffness and viscosity. More than 1 year after the mechanical measurements, the subject was admitted to the Operational Unit of Diabetology of the Policlinico Gemelli Hospital with high blood glucose and glycosylated hemoglobin (HbA1c) levels and diagnosed with type 1 diabetes (T1DM). Here, we show these data, and we discuss the hypothesis that RBC mechanical properties could be sensitive to changes occurring during the pre-diabetic phase of T1DM.
Identifiants
pubmed: 33117782
doi: 10.3389/fbioe.2020.569978
pmc: PMC7552738
doi:
Types de publication
Case Reports
Langues
eng
Pagination
569978Informations de copyright
Copyright © 2020 Di Giacinto, Tartaglione, Nardini, Mazzini, Romanò, Rizzo, Papi, De Spirito, Pitocco and Ciasca.
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