Tissue-disruption-induced cellular stochasticity and epigenetic drift: Common origins of aging and cancer?
cell-cell interaction
intratumoral heterogeneity
oncogenesis
stochastic gene expression
systemic aging
Journal
BioEssays : news and reviews in molecular, cellular and developmental biology
ISSN: 1521-1878
Titre abrégé: Bioessays
Pays: United States
ID NLM: 8510851
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
10
06
2020
revised:
22
09
2020
accepted:
24
09
2020
pubmed:
30
10
2020
medline:
19
8
2021
entrez:
29
10
2020
Statut:
ppublish
Résumé
Age-related and cancer-related epigenomic modifications have been associated with enhanced cell-to-cell gene expression variability that characterizes increased cellular stochasticity. Since gene expression variability appears to be highly reduced by-and epigenetic and phenotypic stability acquired through-direct or long-range cellular interactions during cell differentiation, we propose a common origin for aging and cancer in the failure to control cellular stochasticity by cell-cell interactions. Tissue-disruption-induced cellular stochasticity associated with epigenetic drift would be at the origin of organ dysfunction because of an increase in phenotypic variation among cells, ultimately leading to cell death and organ failure through a loss of coordination in cellular functions, and eventually to cancerization. We propose mechanistic research perspectives to corroborate this hypothesis and explore its evolutionary consequences, highlighting a positive correlation between the median age of mass loss onset (a proxy for the onset of organ aging) and the median age at cancer diagnosis.
Identifiants
pubmed: 33118188
doi: 10.1002/bies.202000140
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2000140Subventions
Organisme : Agence Nationale de la Recherche
ID : ANR-18-CE35-0009
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2020 Wiley Periodicals LLC.
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