The role of B7 family members in the generation of Immunoglobulin.
B7 family
Ig
follicular T helper (Tfh) cell
germinal center (GC) B cell
Journal
Journal of leukocyte biology
ISSN: 1938-3673
Titre abrégé: J Leukoc Biol
Pays: England
ID NLM: 8405628
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
05
01
2020
revised:
08
04
2020
accepted:
15
04
2020
pubmed:
30
10
2020
medline:
24
3
2021
entrez:
29
10
2020
Statut:
ppublish
Résumé
Ig is a Y-shaped protein produced by plasma cells and exerts multiple functions in humoral immunity. There are five groups of Igs including IgA, IgD, IgE, IgG, and IgM, which differ in their heavy chain class. The primary function of Igs includes the neutralization of extrinsic pathogens, agglutination of foreign cells for phagocytosis, precipitation of soluble antigens in serum, and complement fixation. The B cells activated by antigen(s) can differentiate into antibody-producing cells that are called plasma cells and usually matured in the germinal center (GC). Follicular T helper (Tfh) cells crosstalk with antigen-presenting cells and play a crucial role in the development of the GC. Moreover, Tfh cells regulate trafficking through the GC to allow formative interaction with GC B cells that ultimately results in affinity maturation, B-cell memory, and Ig class switching. The B7 family is a series of number of structurally related membrane proteins that bind with a specific receptor to deliver costimulatory or co-inhibitory signals that regulate the activation of T cells in GC. Here, we review and summarize the recent advance of the effects of B7 family members on Ig production and relative diseases.
Identifiants
pubmed: 33118237
doi: 10.1002/JLB.1MR0420-003RR
doi:
Substances chimiques
Antigens, CD
0
B7 Antigens
0
Immunoglobulins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
377-382Subventions
Organisme : Zhujiang Innovative and Entrepreneurial Talent Team Award of Guangdong Province
ID : 2016ZT06S252
Organisme : National Natural Science Foundation of China
ID : 81871224
Organisme : National Natural Science Foundation of China
ID : 81671611
Organisme : National Natural Science Foundation of China
ID : 81901657
Organisme : NIH HHS
ID : R01 AR059103
Pays : United States
Organisme : NIH HHS
ID : R01 AR059103
Pays : United States
Informations de copyright
©2020 Society for Leukocyte Biology.
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