Fecal microbiota transplantation in the intestinal decolonization of carbapenamase-producing enterobacteriaceae.
Journal
Revista espanola de enfermedades digestivas
ISSN: 1130-0108
Titre abrégé: Rev Esp Enferm Dig
Pays: Spain
ID NLM: 9007566
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
pubmed:
30
10
2020
medline:
29
6
2021
entrez:
29
10
2020
Statut:
ppublish
Résumé
fecal microbiota transplantation (FMT) is effective for recurrent Clostridium difficile infection (CDI). Intestinal decolonization of carbapenamase-producing enterobacteriaceae (CPE) can prevent transmission and infection by these agents. The aim of this study was to assess CPE decolonization after FMT. this was a case-series study that consecutively included all CPE-carriers that underwent FMT between 2014 and 2019. The indications included refractory/recurrent CDI and CPE-decolonization. out of 21 CPE-carriers, eight were excluded due to incomplete post-FMT testing. CPE decolonization was confirmed in 76.9 % (n = 10). The median decolonization time was 16-weeks (IQR-23) and ranged from two to 53 weeks. FMT may be used in the clinical practice for CPE-decolonization as an alternative to combined antibiotic regimens.
Sections du résumé
BACKGROUND AND AIMS
OBJECTIVE
fecal microbiota transplantation (FMT) is effective for recurrent Clostridium difficile infection (CDI). Intestinal decolonization of carbapenamase-producing enterobacteriaceae (CPE) can prevent transmission and infection by these agents. The aim of this study was to assess CPE decolonization after FMT.
METHODS
METHODS
this was a case-series study that consecutively included all CPE-carriers that underwent FMT between 2014 and 2019. The indications included refractory/recurrent CDI and CPE-decolonization.
RESULTS
RESULTS
out of 21 CPE-carriers, eight were excluded due to incomplete post-FMT testing. CPE decolonization was confirmed in 76.9 % (n = 10). The median decolonization time was 16-weeks (IQR-23) and ranged from two to 53 weeks.
CONCLUSION
CONCLUSIONS
FMT may be used in the clinical practice for CPE-decolonization as an alternative to combined antibiotic regimens.
Identifiants
pubmed: 33118360
doi: 10.17235/reed.2020.7150/2020
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM