Exosomes: Novel Players of Therapy Resistance in Neuroblastoma.
Antibody-dependent cell cytotoxicity
Chemotherapy
Disialoganglioside
Exosome biogenesis
Exosomes
Extracellular vesicles
Immunotherapy
MYCN
Metastasis
Multivesicular bodies
Neuroblastoma
Non-coding RNAs
Pericytes
Tumor microenvironment
Tumor-associated monocytes
Journal
Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
29
10
2020
pubmed:
30
10
2020
medline:
14
1
2021
Statut:
ppublish
Résumé
Neuroblastoma is a solid tumor (a lump or mass), often found in the small glands on top of the kidneys, and most commonly affects infants and young children. Among neuroblastomas, high-risk neuroblastomas are very aggressive and resistant to most kinds of intensive treatment. Immunotherapy, which uses the immune system to fight against cancer, has shown great promise in treating many types of cancer. However, high-risk neuroblastoma is often resistant to this approach as well. Recent studies revealed that small vesicles known as exosomes, which are envelopes, could deliver a cargo of small RNA molecules and provide communication between neuroblastoma cells and the surrounding cells and trigger metastasis and resistance to immunotherapy. In this chapter, we describe the role of exosomes and small RNA molecules in the metastasis and regression of neuroblastoma and the potential therapeutic approaches to combat this menace.
Identifiants
pubmed: 33119866
doi: 10.1007/978-3-030-50224-9_5
pmc: PMC7775408
mid: NIHMS1656255
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
75-85Subventions
Organisme : NCI NIH HHS
ID : K22 CA197074
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA036727
Pays : United States
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