Coagulation Changes during Central Hypovolemia across Seasons.
LBNP
coagulation
seasons
thrombelastometry
thrombin generation
trhombogram
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
27 Oct 2020
27 Oct 2020
Historique:
received:
23
09
2020
revised:
21
10
2020
accepted:
26
10
2020
entrez:
30
10
2020
pubmed:
31
10
2020
medline:
31
10
2020
Statut:
epublish
Résumé
Lower body negative pressure (LBNP) application simulates hemorrhage. We investigated how seasons affect coagulation values at rest and during LBNP. Healthy participants were tested in cold (November-April) and warm (May-October) months. Following a 30-min supine period, LBNP was started at -10 mmHg and increased by -10 mmHg every five minutes until a maximum of -40 mmHg. Recovery was for 10 min. Blood was collected at baseline, end of LBNP, and end of recovery. Hemostatic profiling included standard coagulation tests, calibrated automated thrombogram, thrombelastometry, impedance aggregometry, and thrombin formation markers. Seven men (25.0 ± 3.6 years, 79.7 ± 7.8 kg weight, 182.4 ± 3.3 cm height, and 23.8 ± 2.3 kg/m
Identifiants
pubmed: 33121195
pii: jcm9113461
doi: 10.3390/jcm9113461
pmc: PMC7692650
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Otto Loewi Center of Research in Vascular Biology, Immunity and Inflammation of the Medical University of Graz
ID : internal research grant
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