Tenascin-C preserves microglia surveillance and restricts leukocyte and, more specifically, T cell infiltration of the ischemic brain.

Animals Brain Brain Ischemia Disease Models, Animal Extracellular Matrix Ischemia Mice Mice, Inbred C57BL Microglia T-Lymphocytes Tenascin
Extracellular matrix Focal cerebral ischemia Microglial activation TnC

Journal

Brain, behavior, and immunity
ISSN: 1090-2139
Titre abrégé: Brain Behav Immun
Pays: Netherlands
ID NLM: 8800478

Informations de publication

Date de publication:
01 2021
Historique:
received: 18 06 2020
revised: 28 09 2020
accepted: 13 10 2020
pubmed: 31 10 2020
medline: 28 5 2021
entrez: 30 10 2020
Statut: ppublish

Résumé

As an endogenous activator of toll-like receptor-4 (Tlr4), the extracellular matrix glycoprotein tenascin-C (TnC) regulates chemotaxis, phagocytosis and proinflammatory cytokine production in microglia. The role of TnC for ischemic brain injury, post-ischemic immune responses and stroke recovery has still not been evaluated. By comparing wild type and TnC

Identifiants

DOI: 10.1016/j.bbi.2020.10.016 PMID: 33122023
pubmed: 33122023
pii: S0889-1591(20)32366-7
doi: 10.1016/j.bbi.2020.10.016
pii:
doi:

Substances chimiques

Tenascin 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

639-648

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Daniel Manrique-Castano (D)

Department of Neurology, University Hospital Essen, Hufelandstraße 55, D-45122 Essen, Germany.

Egor Dzyubenko (E)

Department of Neurology, University Hospital Essen, Hufelandstraße 55, D-45122 Essen, Germany.

Mina Borbor (M)

Department of Neurology, University Hospital Essen, Hufelandstraße 55, D-45122 Essen, Germany.

Paraskevi Vasileiadou (P)

Department of Neurology, University Hospital Essen, Hufelandstraße 55, D-45122 Essen, Germany.

Christoph Kleinschnitz (C)

Department of Neurology, University Hospital Essen, Hufelandstraße 55, D-45122 Essen, Germany.

Lars Roll (L)

Department of Cell Morphology and Molecular Neurobiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Universitätsstraße 150, D-44801 Bochum, Germany.

Andreas Faissner (A)

Department of Cell Morphology and Molecular Neurobiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Universitätsstraße 150, D-44801 Bochum, Germany. Electronic address: andreas.faissner@rub.de.

Dirk M Hermann (DM)

Department of Neurology, University Hospital Essen, Hufelandstraße 55, D-45122 Essen, Germany. Electronic address: dirk.hermann@uk-essen.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Tenascin-C preserves microglia surveillance...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tenascin-C preserves microglia surveillance...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Encéphalopathie ischémique › Tenascin-C preserves microglia surveillance...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Tenascin-C preserves microglia surveillance...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Matrice extracellulaire › Tenascin-C preserves microglia surveillance...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Ischémie › Tenascin-C preserves microglia surveillance...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Tenascin-C preserves microglia surveillance...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Tenascin-C preserves microglia surveillance...
questionsmedicales.fr › Cellules › Névroglie › Microglie › Tenascin-C preserves microglia surveillance...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Tenascin-C preserves microglia surveillance...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Protéines de la matrice extracellulaire › Ténascine › Tenascin-C preserves microglia surveillance...