Incidence and predictors of ophthalmic artery occlusion in intra-arterial chemotherapy for retinoblastoma.
Antineoplastic Agents
/ administration & dosage
Catheterization
/ methods
Child, Preschool
Cohort Studies
Female
Humans
Incidence
Infant
Infusions, Intra-Arterial
/ methods
Male
Ophthalmic Artery
/ diagnostic imaging
Predictive Value of Tests
Retinal Neoplasms
/ diagnostic imaging
Retinoblastoma
/ diagnostic imaging
Retrospective Studies
Treatment Outcome
intervention
tumor
Journal
Journal of neurointerventional surgery
ISSN: 1759-8486
Titre abrégé: J Neurointerv Surg
Pays: England
ID NLM: 101517079
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
13
08
2020
revised:
28
09
2020
accepted:
29
09
2020
pubmed:
31
10
2020
medline:
21
7
2021
entrez:
30
10
2020
Statut:
ppublish
Résumé
Retinoblastoma is the most common primary intraocular malignancy in children. To determine the incidence of ophthalmic artery (OA) occlusion in patients treated with selective ophthalmic artery catheterization (OAC) for chemotherapy infusion for retinoblastoma. Also, to evaluate technical, anatomical, tumorous, and patient-related factors that are predictors of OA occlusion. A retrospective chart review was performed for patients diagnosed with intraocular retinoblastoma and managed with intra-arterial chemotherapy (IAC). The total study cohort included 208 retinoblastoma tumors of 208 eyes in 197 consecutive patients who underwent 688 attempted IAC infusions overall with a total of 624 successful OAC infusions. The total incidence of ophthalmic artery thrombosis was 11.1% (23/208). The numbers of successful OAC procedures before diagnosing OA occlusion were one OAC in six cases (27.3%), two in seven cases (31.8%), three in four cases (18.2%), four in one case (4.5%), five in two cases (9.1%), and six in one case (4.5%). Local factors relating to the chemotherapy and selective microcatheterization of the OA are essential factors in the development of OA thrombosis, as seen by the association of OA thrombosis with the frequency of IAC.
Sections du résumé
BACKGROUND
BACKGROUND
Retinoblastoma is the most common primary intraocular malignancy in children.
OBJECTIVE
OBJECTIVE
To determine the incidence of ophthalmic artery (OA) occlusion in patients treated with selective ophthalmic artery catheterization (OAC) for chemotherapy infusion for retinoblastoma. Also, to evaluate technical, anatomical, tumorous, and patient-related factors that are predictors of OA occlusion.
METHODS
METHODS
A retrospective chart review was performed for patients diagnosed with intraocular retinoblastoma and managed with intra-arterial chemotherapy (IAC).
RESULTS
RESULTS
The total study cohort included 208 retinoblastoma tumors of 208 eyes in 197 consecutive patients who underwent 688 attempted IAC infusions overall with a total of 624 successful OAC infusions. The total incidence of ophthalmic artery thrombosis was 11.1% (23/208). The numbers of successful OAC procedures before diagnosing OA occlusion were one OAC in six cases (27.3%), two in seven cases (31.8%), three in four cases (18.2%), four in one case (4.5%), five in two cases (9.1%), and six in one case (4.5%).
CONCLUSIONS
CONCLUSIONS
Local factors relating to the chemotherapy and selective microcatheterization of the OA are essential factors in the development of OA thrombosis, as seen by the association of OA thrombosis with the frequency of IAC.
Identifiants
pubmed: 33122349
pii: neurintsurg-2020-016759
doi: 10.1136/neurintsurg-2020-016759
doi:
Substances chimiques
Antineoplastic Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
652-656Informations de copyright
© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: PJ is a consultant for Medtronic and MicroVention. SIT is a consultant for Stryker. The other authors have no personal, financial, or institutional interest in any of the drugs, materials, or devices described in this article.