Delineating colorectal cancer distribution, interaction, and risk prediction by environmental risk factors and serum trace elements.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
29 10 2020
29 10 2020
Historique:
received:
07
04
2020
accepted:
20
10
2020
entrez:
30
10
2020
pubmed:
31
10
2020
medline:
31
3
2021
Statut:
epublish
Résumé
The burden of colorectal cancer (CRC) is increasing worldwide especially in developing countries. This phenomenon may be attributable to lifestyle, dietary and environmental risk factors. We aimed to determine the level of 25 trace elements, their interaction with environmental risk factors, and subsequently develop a risk prediction model for CRC (RPM CRC). For the discovery phase, we used a hospital-based case-control study (CRC and non-CRC patients) and in the validation phase we analysed pre-symptomatic samples of CRC patients from The Malaysian Cohort Biobank. Information on the environmental risk factors were obtained and level of 25 trace elements measured using the ICP-MS method. CRC patients had lower Zn and Se levels but higher Li, Be, Al, Co, Cu, As, Cd, Rb, Ba, Hg, Tl, and Pb levels compared to non-CRC patients. The positive interaction between red meat intake ≥ 50 g/day and Co ≥ 4.77 µg/L (AP 0.97; 95% CI 0.91, 1.03) doubled the risk of CRC. A panel of 24 trace elements can predict simultaneously and accurate of high, moderate, and low risk of CRC (accuracy 100%, AUC 1.00). This study provides a new input on possible roles for various trace elements in CRC as well as using a panel of trace elements as a screening approach to CRC.
Identifiants
pubmed: 33122698
doi: 10.1038/s41598-020-75760-9
pii: 10.1038/s41598-020-75760-9
pmc: PMC7596468
doi:
Substances chimiques
Trace Elements
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
18670Commentaires et corrections
Type : ErratumIn
Références
Nutrients. 2017 May 18;9(5):
pubmed: 28524104
Int J Clin Oncol. 2012 Dec;17(6):575-83
pubmed: 21968912
J Clin Med. 2018 Jan 30;7(2):
pubmed: 29385768
Crit Rev Toxicol. 2009;39 Suppl 1:1-32
pubmed: 19384680
Biol Trace Elem Res. 2016 Apr;170(2):294-9
pubmed: 26329996
Biol Trace Elem Res. 2012 Dec;150(1-3):200-7
pubmed: 22983774
Acta Obstet Gynecol Scand. 2018 Apr;97(4):417-423
pubmed: 29453880
Int J Mol Sci. 2018 Feb 06;19(2):
pubmed: 29415457
Front Public Health. 2017 Sep 08;5:234
pubmed: 28944221
Nutr Rev. 2014 May;72(5):334-52
pubmed: 24739133
J Surg Oncol. 1993 Mar;52(3):172-5
pubmed: 8441275
Int J Epidemiol. 2015 Apr;44(2):423-31
pubmed: 24729425
Meat Sci. 2006 Dec;74(4):644-7
pubmed: 22063217
World J Gastrointest Oncol. 2012 Apr 15;4(4):68-70
pubmed: 22532878
Int J Cancer. 2015 Mar 1;136(5):E359-86
pubmed: 25220842
Clin Chim Acta. 2011 Nov 20;412(23-24):2305-9
pubmed: 21910977
PLoS One. 2013 Dec 10;8(12):e83060
pubmed: 24340079
Neurotoxicology. 2014 Mar;41:154-66
pubmed: 24560992
Carcinogenesis. 2017 Jul 1;38(7):699-707
pubmed: 28575311
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2012 Aug;29(8):1322-33
pubmed: 22656325
J Nutr. 2000 May;130(5S Suppl):1374S-7S
pubmed: 10801946
Pol J Pathol. 2011 Dec;62(4):257-61
pubmed: 22246912
N Engl J Med. 2002 Jan 3;346(1):40-4
pubmed: 11778002
Toxicology. 2014 Mar 20;317:17-30
pubmed: 24462659
Sci Rep. 2015 Jul 16;5:12249
pubmed: 26179508
Am J Clin Nutr. 2014 Jul;100 Suppl 1:386S-93S
pubmed: 24847855
Cancer Causes Control. 2007 Feb;18(1):7-27
pubmed: 17186419
Nutrients. 2018 Dec 24;11(1):
pubmed: 30586919
Porto Biomed J. 2016 Mar-Apr;1(1):25-28
pubmed: 32258542
Am J Epidemiol. 1998 Aug 1;148(3):241-8
pubmed: 9690360
IUBMB Life. 2016 Feb;68(2):97-105
pubmed: 26714931
Crit Rev Food Sci Nutr. 2016 Dec 9;56(16):2747-66
pubmed: 25975275
Nutrients. 2017 Jul 18;9(7):
pubmed: 28718824
Clin Med Insights Oncol. 2014 Jan 09;8:1-13
pubmed: 24453505
Gut. 2017 Apr;66(4):683-691
pubmed: 26818619
Mutat Res. 2003 Dec 10;533(1-2):107-20
pubmed: 14643415
Dtsch Arztebl Int. 2017 Sep 29;114(39):653-659
pubmed: 29034866
Indian J Med Res. 2013 Feb;137(2):339-45
pubmed: 23563378
Environ Toxicol Pharmacol. 2017 Dec;56:383-392
pubmed: 29145169
Sci Rep. 2016 Oct 18;6:35097
pubmed: 27752066
Prz Gastroenterol. 2016;11(1):24-9
pubmed: 27110307
mBio. 2012 Jul 31;3(4):e00171-12
pubmed: 22851657
BMC Obes. 2015 Nov 24;2:46
pubmed: 26623077
Inflammopharmacology. 2017 Feb;25(1):11-24
pubmed: 28083748
PLoS One. 2018 Jan 5;13(1):e0184873
pubmed: 29304040
Int Braz J Urol. 2015 Nov-Dec;41(6):1101-7
pubmed: 26742967
J Gastrointest Cancer. 2012 Jun;43(2):249-57
pubmed: 21373779
J Clin Oncol. 2016 Dec 10;34(35):4277-4283
pubmed: 27903152
Biol Trace Elem Res. 2012 Feb;145(2):127-35
pubmed: 21870153
Biol Trace Elem Res. 2001 Feb;79(2):107-14
pubmed: 11330516
Cancer Prev Res (Phila). 2016 Jan;9(1):13-26
pubmed: 26464100
Antioxidants (Basel). 2017 Mar 29;6(2):
pubmed: 28353636
PLoS One. 2017 Jul 24;12(7):e0179360
pubmed: 28742092
Biol Trace Elem Res. 2007 Jun;116(3):257-72
pubmed: 17709906
Pract Lab Med. 2019 Oct 16;18:e00142
pubmed: 31720354
Acta Cir Bras. 2016;31 Suppl 1:24-8
pubmed: 27142901
3 Biotech. 2013 Apr;3(2):85-96
pubmed: 28324563
Comput Math Methods Med. 2017;2017:3762651
pubmed: 28642804
World J Gastroenterol. 2017 Jul 28;23(28):5086-5096
pubmed: 28811705