Associations of central and peripheral blood pressure with the renin-angiotensin-aldosterone system in healthy young adults: the African-PREDICT study.
African
Aldosterone
Angiotensin II
Black
Central systolic blood pressure
Renin
Journal
Hypertension research : official journal of the Japanese Society of Hypertension
ISSN: 1348-4214
Titre abrégé: Hypertens Res
Pays: England
ID NLM: 9307690
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
07
08
2020
accepted:
17
09
2020
revised:
07
09
2020
pubmed:
31
10
2020
medline:
25
12
2021
entrez:
30
10
2020
Statut:
ppublish
Résumé
This study investigated associations of brachial and central blood pressure (BP) with detailed renin-angiotensin-aldosterone system (RAAS) components in a healthy young population stratified according to ethnicity and sex. We included healthy black men (n = 285) and women (n = 304) and white men (n = 278) and women (n = 305) aged 20-30 years old. We derived central systolic BP (cSBP), measured clinic and 24-h systolic and diastolic BP. Aldosterone and equilibrium angiotensin levels were assessed and used for calculating angiotensin-derived markers for plasma renin activity (PRA-S, Angiotensin I + Angiotensin II), angiotensin-converting enzyme (ACE-S, Angiotensin II/Angiotensin I), and two markers for adrenal effects of angiotensin II, the aldosterone-to-renin ratio (ARR-S, Aldosterone/PRA-S) and the aldosterone-to-angiotensin II-ratio (AA2-R, Aldosterone/Angiotensin II)
Identifiants
pubmed: 33122821
doi: 10.1038/s41440-020-00566-1
pii: 10.1038/s41440-020-00566-1
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
435-445Subventions
Organisme : Medical Research Council
ID : MC_PC_16095
Pays : United Kingdom
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