Follicle-stimulating hormone receptor gene polymorphisms of ovarian reserve markers in Romanian population.
estradiol
follicle
infertility
polymorphism
progesterone
prolactin
Journal
Experimental and therapeutic medicine
ISSN: 1792-0981
Titre abrégé: Exp Ther Med
Pays: Greece
ID NLM: 101531947
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
29
07
2020
accepted:
27
08
2020
entrez:
30
10
2020
pubmed:
31
10
2020
medline:
31
10
2020
Statut:
ppublish
Résumé
Association between phenotype and follicle-stimulating hormone (FSH) receptor and FSH beta chain genotype was evaluated in women with ovarian dysfunction. FSH receptor gene single nucleotide polymorphisms (SNPs) were analyzed by restricted fragment length polymorphism (RFLP) technique. Three groups were analyzed: two groups formed of poor responders (women with ovarian dysfunctions caused by endometriosis and patients who underwent ovarian stimulation protocols) and a third good responders group (normal-ovulatory women who gave birth to naturally conceived children). A higher average level of basal FSH values were found in mutants in the A919G/Ala307Thr/rs6165 or A2039G/Asn680Ser/rs6166 tests (7.16±1.09; P=0.659). Anti-mullerian hormone (AMH) below 1.2 ng/ml was associated with a higher frequency of mutations: 33.3% A919G/Ala307Thr and A2039G/Asn680Ser (P=0.137) and also in 66.6% FSH receptor less frequent polymorphism (c.-29G>A) rs 1394205 (P=0.522). The age, day 3 FSH, and AMH levels are widely used to investigate female infertility. However, we have not yet found the ideal biomarker to determine the best outcome and treatment plan for our patients. We cconsider that genetic markers will become the future in the personalization of controlled ovarian stimulation treatment in the upcoming period.
Identifiants
pubmed: 33123232
doi: 10.3892/etm.2020.9333
pii: ETM-0-0-09333
pmc: PMC7588789
doi:
Types de publication
Journal Article
Langues
eng
Pagination
203Informations de copyright
Copyright: © Tănase et al.
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