A case report of an acute coronary syndrome in a 10-year-old boy with homozygous familial hypercholesterolaemia.
Acute coronary syndrome
Case report
Homozygous familial hypercholesterolaemia
LDL cholesterol
Journal
European heart journal. Case reports
ISSN: 2514-2119
Titre abrégé: Eur Heart J Case Rep
Pays: England
ID NLM: 101730741
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
04
04
2019
revised:
30
04
2019
accepted:
04
12
2019
entrez:
30
10
2020
pubmed:
31
10
2020
medline:
31
10
2020
Statut:
epublish
Résumé
Familial hypercholesterolaemia is a well-known disorder, but clinical diagnoses tend to be delayed. Acute coronary syndrome may occur in childhood. Our patient, a young boy with homozygous familial hypercholesterolaemia, complained of persistent chest pain at rest and suffered a non-ST-elevation myocardial infarction (NSTEMI). The diagnosis of NSTEMI was made on the basis of his clinical features, dynamic electrocardiogram changes, troponin elevation, and cardiac computed tomography findings. The patient was managed surgically by intrathoracic artery (ITA) bypass graft. During post-operative follow-up, the young patient suffered from angina pectoris from unexpected and exceptional atheroma stenosis on the ITA. Familial hypercholesterolaemia needs to be identified quickly in young patients and lipid lowering therapies should be started without delay.
Sections du résumé
BACKGROUND
BACKGROUND
Familial hypercholesterolaemia is a well-known disorder, but clinical diagnoses tend to be delayed. Acute coronary syndrome may occur in childhood.
CASE SUMMARY
METHODS
Our patient, a young boy with homozygous familial hypercholesterolaemia, complained of persistent chest pain at rest and suffered a non-ST-elevation myocardial infarction (NSTEMI). The diagnosis of NSTEMI was made on the basis of his clinical features, dynamic electrocardiogram changes, troponin elevation, and cardiac computed tomography findings. The patient was managed surgically by intrathoracic artery (ITA) bypass graft. During post-operative follow-up, the young patient suffered from angina pectoris from unexpected and exceptional atheroma stenosis on the ITA.
DISCUSSION
CONCLUSIONS
Familial hypercholesterolaemia needs to be identified quickly in young patients and lipid lowering therapies should be started without delay.
Identifiants
pubmed: 33123673
doi: 10.1093/ehjcr/ytz233
pii: ytz233
pmc: PMC7574956
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1-5Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of the European Society of Cardiology.
Références
Circulation. 2002 May 28;105(21):2469-75
pubmed: 12034651
Eur Heart J. 2014 Aug 21;35(32):2146-57
pubmed: 25053660
Eur Heart J. 2018 Apr 7;39(14):1162-1168
pubmed: 29106543
Iran J Pediatr. 2016 Feb;26(1):e3875
pubmed: 26848378
J Am Coll Cardiol. 2017 Aug 29;70(9):1162-1170
pubmed: 28838366
Circ Cardiovasc Genet. 2016 Dec;9(6):504-510
pubmed: 27784735
Lancet Diabetes Endocrinol. 2017 Apr;5(4):280-290
pubmed: 28215937
Atherosclerosis. 2016 Dec;255:128-139
pubmed: 27839699
Circulation. 2011 Nov 15;124(20):2202-7
pubmed: 21986285
Atherosclerosis. 2017 Feb;257:130-137
pubmed: 28131047
Lancet Diabetes Endocrinol. 2016 Oct;4(10):850-61
pubmed: 27246162
Curr Opin Lipidol. 2015 Jun;26(3):200-9
pubmed: 25950706
Int J Cardiovasc Imaging. 2012 Dec;28(8):2109-19
pubmed: 22212661