Emerging Role of Nef in the Development of HIV Associated Neurological Disorders.
Autophagy
Exosome
HAND
HIV-1 Nef
Journal
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
ISSN: 1557-1904
Titre abrégé: J Neuroimmune Pharmacol
Pays: United States
ID NLM: 101256586
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
24
04
2020
accepted:
08
10
2020
pubmed:
31
10
2020
medline:
15
12
2021
entrez:
30
10
2020
Statut:
ppublish
Résumé
Despite adherence to treatment, individuals living with HIV have an increased risk for developing cognitive impairments, referred to as HIV-associated neurological disorders (HAND). Due to continued growth in the HIV population, particularly amongst the aging cohort, the neurobiological mechanisms of HAND are increasingly relevant. Similar to other viral proteins (e.g. Tat, Gp120, Vpr), the Negative Factor (Nef) is associated with numerous adverse effects in the CNS as well as cognitive impairments. In particular, emerging data indicate the consequences of Nef may be facilitated by the modulation of cellular autophagy as well as its inclusion into extracellular vesicles (EVs). The present review examines evidence for the molecular mechanisms by which Nef might contribute to neuronal dysfunction underlying HAND, with a specific focus on autophagy and EVs. Based on the these data, we propose an integrated model by which Nef may contribute to underlying neuronal dysfunction in HAND and highlight potentially novel therapeutic targets for HAND. Graphical abstract.
Identifiants
pubmed: 33123948
doi: 10.1007/s11481-020-09964-1
pii: 10.1007/s11481-020-09964-1
pmc: PMC8081738
mid: NIHMS1642518
doi:
Substances chimiques
nef Gene Products, Human Immunodeficiency Virus
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
238-250Subventions
Organisme : NIMH NIH HHS
ID : P30 MH092177
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH079785
Pays : United States
Organisme : NIH HHS
ID : P30MH092177
Pays : United States
Organisme : NIH HHS
ID : T32MH079785
Pays : United States
Organisme : NIH HHS
ID : T32MH079785
Pays : United States
Organisme : NIH HHS
ID : P30MH092177
Pays : United States
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