Comparison between a flash glucose monitoring system and a portable blood glucose meter for monitoring dogs with diabetes mellitus.
FreeStyle Libre
canine
diabetes mellitus
interstitial glucose
Journal
Journal of veterinary internal medicine
ISSN: 1939-1676
Titre abrégé: J Vet Intern Med
Pays: United States
ID NLM: 8708660
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
01
02
2020
revised:
22
09
2020
accepted:
25
09
2020
pubmed:
31
10
2020
medline:
29
6
2021
entrez:
30
10
2020
Statut:
ppublish
Résumé
Flash glucose monitoring system (FGMS; FreeStyle Libre) was recently validated for use in diabetic dogs (DD). It is not known if this system is clinically useful in monitoring DD. To compare the clinical utility of FGMS against blood glucose curves (BGCs) obtained with a portable blood glucose meter (PBGM) in monitoring DD. Twenty dogs with diabetes mellitus. Prospective study. Dogs with diabetes mellitus on insulin treatment for at least 1 month were included. Comparisons of insulin dose recommendations based on the in-hospital GCs acquired using FGMS and a PBGM, consecutive-day interstitial GCs (IGCs) acquired at home using the FGMS, and consecutive-day, home vs hospital IGCs acquired using the FGMS were made using concordance analysis. There was good concordance between insulin dose recommendations based on FGMS and PBGM generated GCs and IGCs obtained in the 2 different environments on 2 consecutive days, but almost absent concordance between IGCs obtained on 2 consecutive days at home. Glucose nadirs were detected in 34/43 (79%) of Ambulatory Glucose Profile (AGP) reports of the FGMS. In comparison, concordant glucose nadirs were identified in 14/34 (41%) BGCs using PBGM. The individual FGMS scans and PBGM identified 60% and 9% of low IG/hypoglycemic episodes, respectively. Insulin dose adjustments based on BGCs can be suboptimal. The FGMS allows a more accurate identification of the glucose nadirs and hypoglycemic episodes compared to the use of a PBGM and assessment of day-to-day variations in glycemic control.
Sections du résumé
BACKGROUND
BACKGROUND
Flash glucose monitoring system (FGMS; FreeStyle Libre) was recently validated for use in diabetic dogs (DD). It is not known if this system is clinically useful in monitoring DD.
OBJECTIVE
OBJECTIVE
To compare the clinical utility of FGMS against blood glucose curves (BGCs) obtained with a portable blood glucose meter (PBGM) in monitoring DD.
ANIMALS
METHODS
Twenty dogs with diabetes mellitus.
METHODS
METHODS
Prospective study. Dogs with diabetes mellitus on insulin treatment for at least 1 month were included. Comparisons of insulin dose recommendations based on the in-hospital GCs acquired using FGMS and a PBGM, consecutive-day interstitial GCs (IGCs) acquired at home using the FGMS, and consecutive-day, home vs hospital IGCs acquired using the FGMS were made using concordance analysis.
RESULTS
RESULTS
There was good concordance between insulin dose recommendations based on FGMS and PBGM generated GCs and IGCs obtained in the 2 different environments on 2 consecutive days, but almost absent concordance between IGCs obtained on 2 consecutive days at home. Glucose nadirs were detected in 34/43 (79%) of Ambulatory Glucose Profile (AGP) reports of the FGMS. In comparison, concordant glucose nadirs were identified in 14/34 (41%) BGCs using PBGM. The individual FGMS scans and PBGM identified 60% and 9% of low IG/hypoglycemic episodes, respectively.
CONCLUSIONS AND CLINICAL IMPORTANCE
CONCLUSIONS
Insulin dose adjustments based on BGCs can be suboptimal. The FGMS allows a more accurate identification of the glucose nadirs and hypoglycemic episodes compared to the use of a PBGM and assessment of day-to-day variations in glycemic control.
Identifiants
pubmed: 33124730
doi: 10.1111/jvim.15930
pmc: PMC7694810
doi:
Substances chimiques
Blood Glucose
0
Insulin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2296-2305Informations de copyright
© 2020 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
Références
Gut. 2015 Jul;64(7):1018-27
pubmed: 25873640
JAMA. 1990 Apr 4;263(13):1802-6
pubmed: 2179591
Diabetes Technol Ther. 2017 Mar;19(3):164-172
pubmed: 28263665
Diabet Med. 1995 Mar;12(3):224-8
pubmed: 7758258
Diabetologia. 1972 Nov;8(5):342-8
pubmed: 4641791
Diabetes Technol Ther. 2017 Sep;19(9):533-540
pubmed: 28930495
Diabetes Care. 2009 Mar;32(3):387-93
pubmed: 19106380
J Am Vet Med Assoc. 2003 Feb 1;222(3):317-21
pubmed: 12564593
J Diabetes Sci Technol. 2009 Sep 01;3(5):1207-14
pubmed: 20144438
Lancet. 2016 Nov 5;388(10057):2254-2263
pubmed: 27634581
J Diabetes Investig. 2017 Jan;8(1):69-74
pubmed: 27391168
Vet J. 2010 Apr;184(1):105-10
pubmed: 19231258
Diabetes Technol Ther. 2015 Nov;17(11):787-94
pubmed: 26171659
J Vet Intern Med. 2018 May;32(3):978-985
pubmed: 29603806
Arch Dis Child. 2017 Jun;102(6):543-549
pubmed: 28137708
Lancet Diabetes Endocrinol. 2019 Mar;7(3):221-230
pubmed: 30115599
J Vet Med Sci. 2013 Jan 31;75(1):113-7
pubmed: 22971722
Diabetes Care. 1980 Jan-Feb;3(1):58-62
pubmed: 6996969
Diabetes. 1970 Sep;19(9):644-55
pubmed: 5469118
Am J Physiol Endocrinol Metab. 2002 May;282(5):E1128-38
pubmed: 11934679
Diabetes Care. 2003 Aug;26(8):2405-9
pubmed: 12882870
J Diabetes Sci Technol. 2014 Jan 1;8(1):89-94
pubmed: 24876543
Br J Nutr. 2010 Jan;103(1):134-40
pubmed: 19674490
Diabetes Technol Ther. 2017 May;19(S2):S44-S50
pubmed: 28541139
Pediatrics. 1993 Jun;91(6):1155-7
pubmed: 8502520
J Diabetes Sci Technol. 2010 Nov 01;4(6):1393-9
pubmed: 21129335
Am J Med. 1991 Apr;90(4):450-9
pubmed: 2012085
Can J Vet Res. 2002 Apr;66(2):108-11
pubmed: 11989731
Diabetes Technol Ther. 2005 Dec;7(6):885-95
pubmed: 16386094
Diabetes. 1977 Aug;26(8):717-25
pubmed: 885295
J Vet Intern Med. 2020 Nov;34(6):2296-2305
pubmed: 33124730
Metabolism. 1971 Dec;20(12):1083-98
pubmed: 5129010
Endocrinology. 1981 Jul;109(1):262-72
pubmed: 7238408
J Diabetes Sci Technol. 2018 May;12(3):630-633
pubmed: 29542347
J Vet Intern Med. 2016 Jul;30(4):983-8
pubmed: 27318663
Diabetes Ther. 2017 Feb;8(1):55-73
pubmed: 28000140
Diabetes. 2013 Dec;62(12):4083-7
pubmed: 24009261
J Small Anim Pract. 2003 Oct;44(10):435-42
pubmed: 14582657
BMJ Open Diabetes Res Care. 2020 Mar;8(1):
pubmed: 32198165
Am J Clin Nutr. 1993 Jun;57(6):908-11
pubmed: 8503361
Diabetes Metab J. 2015 Aug;39(4):273-82
pubmed: 26301188
J Am Anim Hosp Assoc. 2004 May-Jun;40(3):171-3
pubmed: 15131096
Am J Vet Res. 2020 Mar;81(3):233-242
pubmed: 32101039
Diabetes Ther. 2020 Jan;11(1):83-95
pubmed: 31673972
Diabetes. 2003 Nov;52(11):2790-4
pubmed: 14578298
Diabetes Technol Ther. 2018 Jan;20(1):17-24
pubmed: 29235898
Diabetologia. 2018 Mar;61(3):539-550
pubmed: 29273897
Diabetes Care. 1984 Mar-Apr;7(2):188-99
pubmed: 6376015
J Vet Intern Med. 2011 Sep-Oct;25(5):1084-8
pubmed: 21985140
Diabetes Care. 2003 Mar;26(3):662-7
pubmed: 12610018
J Diabetes Sci Technol. 2017 Mar;11(2):290-295
pubmed: 27559031
J Small Anim Pract. 2003 Jul;44(7):298-305
pubmed: 12866927
J Vet Intern Med. 2008 Jan-Feb;22(1):2-8
pubmed: 18289283