Lactobacillus bulgaricus and Lactobacillus plantarum improve diabetic wound healing through modulating inflammatory factors.
Animals
Cell Survival
/ drug effects
Cells, Cultured
Diabetes Mellitus
/ drug therapy
Humans
Inflammation
/ drug therapy
Interleukin-10
Interleukin-1beta
/ metabolism
Lactobacillus delbrueckii
/ chemistry
Lactobacillus plantarum
/ chemistry
Mice
Probiotics
/ pharmacology
Rats
Rats, Wistar
Transforming Growth Factor beta
/ metabolism
Tumor Necrosis Factor-alpha
/ metabolism
Wound Healing
/ drug effects
diabetic wound
inflammation
lactobacillus bulgaricus
lactobacillus plantarum
probiotic
wound healing
Journal
Biotechnology and applied biochemistry
ISSN: 1470-8744
Titre abrégé: Biotechnol Appl Biochem
Pays: United States
ID NLM: 8609465
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
pubmed:
31
10
2020
medline:
22
1
2022
entrez:
30
10
2020
Statut:
ppublish
Résumé
Probiotics are nonpathogenic bacterial strains that exert beneficial effects on the host. Previous studies have shown that topical use of some strains of probiotic bacteria have good effects on the healing of cutaneous wounds. In the current study, the wound healing potentials of bacterial probiotics on diabetic cutaneous wounds were evaluated. The effects of probiotics on migration, the viability of fibroblasts, and macrophage proliferation were measured through using wound healing assay, methylthiazol tetrazolium assay, and bromodeoxyuridine, respectively. In this regard, in vivo diabetic wound healing experiments in Wistar rats following treatment with nontoxic concentrations of Lactobacillus bulgaricus and Lactobacillus plantarum were conducted. The histopathological and gene expression analyses were performed following removal of wound sites 3, 7, and 14 days postwounding. Results showed that treatment with probiotics accelerated the healing process of diabetic wounds and modulated the inflammatory cells in wound sites during a 14-day period postwounding. The altered mRNA levels of inflammatory cytokines were observed in wound sites following treatment with probiotics. The findings of the current study reveal that L. bulgaricus and L. plantarum could improve the healing of diabetic wounds via regulation of inflammation.
Substances chimiques
Interleukin-1beta
0
Transforming Growth Factor beta
0
Tumor Necrosis Factor-alpha
0
Interleukin-10
130068-27-8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1421-1431Informations de copyright
© 2020 International Union of Biochemistry and Molecular Biology, Inc.
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