High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer's and Non-Alzheimer's Disease Tauopathies.

Aged Alzheimer Disease / diagnostic imaging Animals Benzothiazoles / metabolism Carbon Radioisotopes / metabolism Female Humans Male Mice Mice, Transgenic Middle Aged Positron-Emission Tomography / methods Tauopathies / diagnostic imaging
Alzheimer’s disease PET Pick's disease corticobasal degeneration frontotemporal lobar degeneration in vivo imaging progressive supranuclear palsy tauopathies tauopathy mouse model translational research

Journal

Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320

Informations de publication

Date de publication:
06 01 2021
Historique:
received: 17 05 2020
revised: 31 08 2020
accepted: 29 09 2020
pubmed: 31 10 2020
medline: 10 2 2021
entrez: 30 10 2020
Statut: ppublish

Résumé

A panel of radiochemicals has enabled in vivo positron emission tomography (PET) of tau pathologies in Alzheimer's disease (AD), although sensitive detection of frontotemporal lobar degeneration (FTLD) tau inclusions has been unsuccessful. Here, we generated an imaging probe, PM-PBB3, for capturing diverse tau deposits. In vitro assays demonstrated the reactivity of this compound with tau pathologies in AD and FTLD. We could also utilize PM-PBB3 for optical/PET imaging of a living murine tauopathy model. A subsequent clinical PET study revealed increased binding of

Identifiants

DOI: 10.1016/j.neuron.2020.09.042 PMID: 33125873
pubmed: 33125873
pii: S0896-6273(20)30766-2
doi: 10.1016/j.neuron.2020.09.042
pii:
doi:

Substances chimiques

Benzothiazoles 0
Carbon Radioisotopes 0
PBB3 compound 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

42-58.e8

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests H. Shimada, M.-R.Z., T.S., and M.H. hold patents on compounds related to the present report (JP 5422782/EP 12 884 742.3/CA2894994/HK1208672).

Auteurs

Kenji Tagai (K)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan; Department of Psychiatry, The Jikei University Graduate School of Medicine, Tokyo 105-8461, Japan.

Maiko Ono (M)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.

Manabu Kubota (M)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan; Department of Psychiatry, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.

Soichiro Kitamura (S)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan; Department of Psychiatry, Nara Medical University, Nara 634-8521, Japan.

Keisuke Takahata (K)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan; Department of Psychiatry, Keio University School of Medicine, Tokyo 160-0016, Japan.

Chie Seki (C)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.

Yuhei Takado (Y)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan. Electronic address: takado.yuhei@qst.go.jp.

Hitoshi Shinotoh (H)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan; Neurology Clinic Chiba, Chiba 263-8555, Japan.

Yasunori Sano (Y)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan; Department of Psychiatry, Keio University School of Medicine, Tokyo 160-0016, Japan.

Yasuharu Yamamoto (Y)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan; Department of Psychiatry, Keio University School of Medicine, Tokyo 160-0016, Japan.

Kiwamu Matsuoka (K)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan; Department of Psychiatry, Nara Medical University, Nara 634-8521, Japan.

Hiroyuki Takuwa (H)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.

Masafumi Shimojo (M)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.

Manami Takahashi (M)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.

Kazunori Kawamura (K)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.

Tatsuya Kikuchi (T)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.

Maki Okada (M)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.

Haruhiko Akiyama (H)

Dementia Research Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.

Hisaomi Suzuki (H)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan; Department of Psychiatry, Keio University School of Medicine, Tokyo 160-0016, Japan; National Hospital Organization Shimofusa Psychiatric Medical Center, Chiba 266-0007, Japan.

Mitsumoto Onaya (M)

National Hospital Organization Shimofusa Psychiatric Medical Center, Chiba 266-0007, Japan.

Takahiro Takeda (T)

Department of Neurology, National Hospital Organization Chibahigashi National Hospital, Chiba 260-8712, Japan.

Kimihito Arai (K)

Department of Neurology, National Hospital Organization Chibahigashi National Hospital, Chiba 260-8712, Japan.

Nobutaka Arai (N)

Laboratory of Neuropathology, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.

Nobuyuki Araki (N)

Department of Neurology, National Hospital Organization Chibahigashi National Hospital, Chiba 260-8712, Japan.

Yuko Saito (Y)

National Center of Neurology and Pathology Brain Bank, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo 187-8551, Japan.

John Q Trojanowski (JQ)

Center for Neurodegenerative Disease Research and Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Virginia M Y Lee (VMY)

Center for Neurodegenerative Disease Research and Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Sushil K Mishra (SK)

Glycoscience Group, National University of Ireland, Galway H91 W2TY, Ireland.

Yoshiki Yamaguchi (Y)

Laboratory of Pharmaceutical Physical Chemistry, Tohoku Medical and Pharmaceutical University, Miyagi 981-8558, Japan.

Yasuyuki Kimura (Y)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan; Department of Clinical and Experimental Neuroimaging, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Aichi 474-8511, Japan.

Masanori Ichise (M)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.

Yutaka Tomita (Y)

Tomita Hospital, Aichi 444-3505, Japan.

Ming-Rong Zhang (MR)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.

Tetsuya Suhara (T)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan; Department of Psychiatry, The Jikei University Graduate School of Medicine, Tokyo 105-8461, Japan.

Masahiro Shigeta (M)

Department of Psychiatry, The Jikei University Graduate School of Medicine, Tokyo 105-8461, Japan.

Naruhiko Sahara (N)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.

Makoto Higuchi (M)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan. Electronic address: higuchi.makoto@qst.go.jp.

Hitoshi Shimada (H)

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › High-Contrast In Vivo Imaging of Tau...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › High-Contrast In Vivo Imaging of Tau...
questionsmedicales.fr › Eucaryotes › Animaux › High-Contrast In Vivo Imaging of Tau...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzothiazoles › High-Contrast In Vivo Imaging of Tau...
questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Radio-isotopes › Radio-isotopes du carbone › High-Contrast In Vivo Imaging of Tau...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › High-Contrast In Vivo Imaging of Tau...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › High-Contrast In Vivo Imaging of Tau...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › High-Contrast In Vivo Imaging of Tau...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › High-Contrast In Vivo Imaging of Tau...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › High-Contrast In Vivo Imaging of Tau...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Tauopathies › High-Contrast In Vivo Imaging of Tau...