Maternal exposure to childhood traumatic events, but not multi-domain psychosocial stressors, predict placental corticotrophin releasing hormone across pregnancy.
Childhood traumatic events
Maternal psychosocial stress
Placental corticotrophin releasing hormone
Stress during pregnancy
Journal
Social science & medicine (1982)
ISSN: 1873-5347
Titre abrégé: Soc Sci Med
Pays: England
ID NLM: 8303205
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
revised:
19
09
2020
accepted:
15
10
2020
pubmed:
31
10
2020
medline:
28
4
2021
entrez:
30
10
2020
Statut:
ppublish
Résumé
Maternal psychosocial stress increases the risk of adverse birth and postnatal outcomes for the mother and child, but the role of maternal exposure to childhood traumatic events (CTE) and multi-domain psychosocial stressors for the level and rise of placental Corticotrophin-Releasing Hormone (pCRH) across pregnancy has been understudied. In a sociodemographically and racially diverse sample of 1303 women (64% Black, 36% White/others) with low-medical risk pregnancies at enrollment from Shelby County, Tennessee, USA, blood samples were drawn twice, corresponding roughly to second and third trimester, and extracted prior to conducting radioimmune assays for pCRH. Mothers reported CTE (physical abuse, sexual abuse, or family violence, in childhood), adulthood traumatic events, and interpersonal violence during pregnancy. Neighborhood crime/deprivation was derived using geospatially-linked objective databases. General linear and mixed models tested associations between stress exposure variables and pCRH levels and rate of rise, adjusting for obstetric/clinical/health related factors. Maternal CTE did not predict pCRH levels at time 1, but positively predicted levels at time 2, and the rate of rise in pCRH across pregnancy. Race did not moderate this association. No additional maternal stress exposures across adulthood or during pregnancy predicted pCRH outcomes. Findings indicate that childhood violence or abuse exposure can become biologically embedded in a manner predicting later prenatal physiology relevant for maternal and offspring health, and that such embedding may be specific to childhood, but not adulthood, stress. Findings also highlight the placental-fetal unit as a mechanistic pathway through which intergenerational transmission of the adverse effects of childhood adversities may occur.
Identifiants
pubmed: 33126094
pii: S0277-9536(20)30680-8
doi: 10.1016/j.socscimed.2020.113461
pmc: PMC9380779
mid: NIHMS1822155
pii:
doi:
Substances chimiques
Adrenocorticotropic Hormone
9002-60-2
Corticotropin-Releasing Hormone
9015-71-8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
113461Subventions
Organisme : NIEHS NIH HHS
ID : P30 ES007033
Pays : United States
Organisme : NIH HHS
ID : UG3 OD023271
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023271
Pays : United States
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
Références
J Neuroendocrinol. 2012 Jul;24(7):1055-64
pubmed: 22375940
PLoS One. 2014 Apr 09;9(4):e94394
pubmed: 24718660
Psychopharmacology (Berl). 2011 Mar;214(1):55-70
pubmed: 20865251
Psychoneuroendocrinology. 2018 Jan;87:166-172
pubmed: 29100173
Obstet Gynecol. 2001 May;97(5 Pt 1):657-63
pubmed: 11339911
Am J Epidemiol. 2009 Jun 1;169(11):1319-26
pubmed: 19363098
Nat Neurosci. 2009 Mar;12(3):342-8
pubmed: 19234457
Dev Psychopathol. 2017 Dec;29(5):1553-1571
pubmed: 29162167
PLoS One. 2012;7(6):e39791
pubmed: 22761903
Psychoneuroendocrinology. 2010 Jul;35(6):820-32
pubmed: 20006448
Biol Psychiatry. 2004 Feb 15;55(4):367-75
pubmed: 14960289
Psychoneuroendocrinology. 2019 Jan;99:166-173
pubmed: 30245329
Dev Neurosci. 2005;27(5):299-305
pubmed: 16137987
Matern Child Health J. 2016 Nov;20(Suppl 1):164-172
pubmed: 27339648
Child Dev. 2001 May-Jun;72(3):736-47
pubmed: 11405579
Annu Rev Dev Psychol. 2019 Dec;1:277-312
pubmed: 32455344
Child Abuse Negl. 2018 Nov;85:174-179
pubmed: 28784309
Horm Behav. 2009 Feb;55(2):292-8
pubmed: 19084531
Neurobiol Dis. 2013 Apr;52:24-37
pubmed: 22426398
Eur J Public Health. 2013 Jun;23(3):485-91
pubmed: 22850187
Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1526-33
pubmed: 17264224
Psychoneuroendocrinology. 2013 Feb;38(2):188-200
pubmed: 22727478
Trauma Violence Abuse. 2020 Oct;21(4):828-843
pubmed: 30249161
Child Abuse Negl. 2016 Jan;51:313-22
pubmed: 26386753
J Clin Endocrinol Metab. 2009 Jun;94(6):2066-74
pubmed: 19258402
JAMA. 2000 Aug 2;284(5):592-7
pubmed: 10918705
Nat Med. 1995 May;1(5):460-3
pubmed: 7585095
Psychol Bull. 2011 Nov;137(6):959-97
pubmed: 21787044
Psychosom Med. 2004 Sep-Oct;66(5):762-9
pubmed: 15385704
J Psychosom Res. 2010 Nov;69(5):503-10
pubmed: 20955870
J Am Acad Child Adolesc Psychiatry. 2007 Nov;46(11):1454-63
pubmed: 18049295
Mol Psychiatry. 2014 May;19(5):544-54
pubmed: 23689533
Br J Obstet Gynaecol. 1995 Feb;102(2):118-22
pubmed: 7756202
Science. 1984 Dec 14;226(4680):1342-4
pubmed: 6334362
J Soc Gynecol Investig. 2001 Mar-Apr;8(2):83-8
pubmed: 11336878
Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1619-23
pubmed: 8643680
Clin Obstet Gynecol. 2008 Jun;51(2):333-48
pubmed: 18463464
Psychosom Med. 2011 Apr;73(3):234-41
pubmed: 21321257
Pediatrics. 2017 Jan;139(1):
pubmed: 27994115
Trends Cogn Sci. 2014 Nov;18(11):580-585
pubmed: 25305194
Dev Psychobiol. 2008 Apr;50(3):232-41
pubmed: 18335490
J Urban Health. 2016 Oct;93(5):758-769
pubmed: 27604615
Ment Retard Dev Disabil Res Rev. 2003;9(3):149-54
pubmed: 12953293
Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18274-8
pubmed: 24145410
Eur J Obstet Gynecol Reprod Biol. 1991 Mar 21;39(1):19-24
pubmed: 1851489
Brain Behav Immun. 2011 Oct;25(7):1468-74
pubmed: 21672624
J Clin Endocrinol Metab. 1987 May;64(5):1054-9
pubmed: 3494036
Psychol Assess. 2000 Jun;12(2):210-24
pubmed: 10887767
J Perinatol. 2015 Aug;35(8):580-4
pubmed: 25789817
Peptides. 2007 Jun;28(6):1155-61
pubmed: 17537545
Psychoneuroendocrinology. 2019 Jul;105:123-137
pubmed: 30578047
BMC Med. 2017 Jul 20;15(1):135
pubmed: 28724431
Neuropsychopharmacology. 2017 Jan;42(1):99-114
pubmed: 27629365
Soc Sci Med. 2017 May;181:191-198
pubmed: 28404321
J Child Psychol Psychiatry. 2008 Oct;49(10):1118-28
pubmed: 19017026
PLoS One. 2018 Dec 28;13(12):e0207235
pubmed: 30592715
Nat Rev Neurosci. 2009 Jun;10(6):434-45
pubmed: 19401723
Am J Psychiatry. 1997 May;154(5):624-9
pubmed: 9137116
Psychoneuroendocrinology. 2012 Jul;37(7):970-9
pubmed: 22154479
Psychoneuroendocrinology. 2018 Dec;98:168-176
pubmed: 30170311
J Public Health (Oxf). 2015 Sep;37(3):445-54
pubmed: 25174044
Child Abuse Negl. 2013 Sep;37(9):664-74
pubmed: 23623446
Matern Child Health J. 2016 Apr;20(4):790-8
pubmed: 26762511
Biol Psychiatry. 2001 Aug 1;50(3):200-4
pubmed: 11513819
Psychoneuroendocrinology. 2012 Sep;37(9):1425-30
pubmed: 22341730
Neurosci Biobehav Rev. 2014 Nov;47:578-91
pubmed: 25454359
J Gerontol B Psychol Sci Soc Sci. 2020 Feb 14;75(3):650-660
pubmed: 29878196
Dev Psychopathol. 2018 Aug;30(3):941-952
pubmed: 30068427
Clin Endocrinol (Oxf). 1994 Feb;40(2):257-62
pubmed: 8137526
Am J Physiol Endocrinol Metab. 2006 Feb;290(2):E282-8
pubmed: 16174654
Biol Psychiatry. 2016 May 15;79(10):831-839
pubmed: 26444076
J Reprod Immunol. 2008 Oct;79(1):50-7
pubmed: 18550178
Psychoneuroendocrinology. 2010 Jan;35(1):179-91
pubmed: 19362426
BMC Psychiatry. 2008 Apr 16;8:24
pubmed: 18412979
J Matern Fetal Neonatal Med. 2008 Nov;21(11):788-95
pubmed: 19031275
Psychosom Med. 2014 Jun;76(5):355-62
pubmed: 24915294
JAMA Psychiatry. 2013 May;70(5):508-15
pubmed: 23553149
Nat Rev Neurosci. 2009 Jun;10(6):423-33
pubmed: 19469026
Neuroendocrinology. 1999 Dec;70(6):451-9
pubmed: 10657738
Child Youth Serv Rev. 2019 May;100:258-266
pubmed: 32518434
J Child Psychol Psychiatry. 2011 Feb;52(2):119-29
pubmed: 20854366
J Child Psychol Psychiatry. 2017 Mar;58(3):222-230
pubmed: 27778344
Psychoneuroendocrinology. 2012 Jun;37(6):818-26
pubmed: 22001010
J Womens Health (Larchmt). 2018 Jul;27(7):903-911
pubmed: 29350573
Mol Psychiatry. 2016 May;21(5):642-9
pubmed: 26033244
Thromb Res. 2004;114(5-6):397-407
pubmed: 15507270
Violence Vict. 2004 Oct;19(5):507-20
pubmed: 15844722
Paediatr Perinat Epidemiol. 2010 Jul 1;24(4):390-7
pubmed: 20618729
J Clin Endocrinol Metab. 2014 Feb;99(2):E199-208
pubmed: 24248185
Horm Behav. 2018 Jun;102:10-22
pubmed: 29630895
Am J Psychiatry. 2018 May 1;175(5):471-479
pubmed: 29495899
J Clin Endocrinol Metab. 2005 Jan;90(1):279-85
pubmed: 15494460
Physiol Rev. 2007 Jul;87(3):873-904
pubmed: 17615391
Arch Gen Psychiatry. 2009 Feb;66(2):162-9
pubmed: 19188538
Proc Natl Acad Sci U S A. 1988 Jul;85(14):5244-8
pubmed: 2839838
Am J Obstet Gynecol. 1999 Jan;180(1 Pt 3):S257-63
pubmed: 9914629
Health Aff (Millwood). 2014 Nov;33(11):1948-57
pubmed: 25367989
J Womens Health (Larchmt). 2009 Sep;18(9):1425-33
pubmed: 19757520
Dev Psychopathol. 2017 Aug;29(3):929-940
pubmed: 27424571
Arch Womens Ment Health. 2015 Oct;18(5):659-71
pubmed: 25956589
Front Behav Neurosci. 2019 May 08;13:80
pubmed: 31133828
J Am Acad Child Adolesc Psychiatry. 2018 Sep;57(9):645-657.e8
pubmed: 30196868
Psychoneuroendocrinology. 2016 May;67:10-7
pubmed: 26855003
Peptides. 2006 Jun;27(6):1457-63
pubmed: 16309788
Biol Res Nurs. 2010 Oct;12(2):125-36
pubmed: 20798157
Am J Obstet Gynecol. 2008 Sep;199(3):317.e1-6
pubmed: 18771998
Neurosci Biobehav Rev. 2015 Aug;55:520-35
pubmed: 26073068
Int J Mol Sci. 2015 Nov 17;16(11):27482-96
pubmed: 26593902
Biol Psychiatry. 2018 Jan 15;83(2):120-127
pubmed: 28842114
Am J Obstet Gynecol. 2004 Oct;191(4):1063-9
pubmed: 15507922
Am J Perinatol. 2013 Jun;30(6):433-50
pubmed: 23059494
Brain Behav Immun. 2016 Mar;53:105-112
pubmed: 26616398
Lancet Public Health. 2017 Aug;2(8):e356-e366
pubmed: 29253477
Soc Sci Med. 2014 Oct;119:284-91
pubmed: 25008479
Front Psychiatry. 2019 Mar 11;10:118
pubmed: 30914979