Id1 and PD-1 Combined Blockade Impairs Tumor Growth and Survival of

KRAS lung adenocarcinoma PD-1 inhibition PD-L1 inhibitor of differentiation

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
28 Oct 2020
Historique:
received: 22 09 2020
revised: 19 10 2020
accepted: 25 10 2020
entrez: 31 10 2020
pubmed: 1 11 2020
medline: 1 11 2020
Statut: epublish

Résumé

The use of PD-1/PD-L1 checkpoint inhibitors in advanced NSCLC is associated with longer survival. However, many patients do not benefit from PD-1/PD-L1 blockade, largely because of immunosuppression. New immunotherapy-based combinations are under investigation in an attempt to improve outcomes.

Identifiants

pubmed: 33126649
pii: cancers12113169
doi: 10.3390/cancers12113169
pmc: PMC7693788
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Fundación Merck Salud
ID : 17-PU-006
Organisme : Regional Government of Navarra
ID : 44/2017

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Auteurs

Iosune Baraibar (I)

Department of Oncology, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
Program in Solid Tumors, Center for Applied Medical Research, Program in Solid Tumors, 31008 Pamplona, Spain.

Marta Roman (M)

Department of Oncology, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
Program in Solid Tumors, Center for Applied Medical Research, Program in Solid Tumors, 31008 Pamplona, Spain.

María Rodríguez-Remírez (M)

Department of Oncology, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
Program in Solid Tumors, Center for Applied Medical Research, Program in Solid Tumors, 31008 Pamplona, Spain.

Inés López (I)

Program in Solid Tumors, Center for Applied Medical Research, Program in Solid Tumors, 31008 Pamplona, Spain.

Anna Vilalta (A)

Department of Oncology, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
Program in Solid Tumors, Center for Applied Medical Research, Program in Solid Tumors, 31008 Pamplona, Spain.

Elisabeth Guruceaga (E)

Bioinformatics Platform, Center for Applied Medical Research, 31008 Pamplona, Spain.

Margarita Ecay (M)

Program in Solid Tumors, Center for Applied Medical Research, Program in Solid Tumors, 31008 Pamplona, Spain.

María Collantes (M)

Program in Solid Tumors, Center for Applied Medical Research, Program in Solid Tumors, 31008 Pamplona, Spain.

Teresa Lozano (T)

Program of Immunology and Immunotherapy, Center for Applied Medical Research, Program of Immunology and Immunotherapy, 31008 Pamplona, Spain.

Diego Alignani (D)

Flow cytometry Core Facility, Center for Applied Medical Research, Flow Cytometry Core Facility, 31008 Pamplona, Spain.
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 31008 Madrid, Spain.

Ander Puyalto (A)

Department of Oncology, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
Program in Solid Tumors, Center for Applied Medical Research, Program in Solid Tumors, 31008 Pamplona, Spain.

Ana Oliver (A)

Department of Oncology, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
Program in Solid Tumors, Center for Applied Medical Research, Program in Solid Tumors, 31008 Pamplona, Spain.

Sergio Ortiz-Espinosa (S)

Program in Solid Tumors, Center for Applied Medical Research, Program in Solid Tumors, 31008 Pamplona, Spain.

Haritz Moreno (H)

Program in Solid Tumors, Center for Applied Medical Research, Program in Solid Tumors, 31008 Pamplona, Spain.

María Torregrosa (M)

Department of Oncology, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
Program in Solid Tumors, Center for Applied Medical Research, Program in Solid Tumors, 31008 Pamplona, Spain.

Christian Rolfo (C)

Thoracic Medical Oncology Program, Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD 21201, USA.

Christian Caglevic (C)

Cancer Research Department, Fundación Arturo Lopez Perez, Santiago de Chile 7500921, Chile.

David García-Ros (D)

Department of Pathology, Anatomy and Physiology, University of Navarra, 31008 Pamplona, Spain.

María Villalba-Esparza (M)

Department of Pathology, Anatomy and Physiology, University of Navarra, 31008 Pamplona, Spain.

Carlos De Andrea (C)

Department of Pathology, Anatomy and Physiology, University of Navarra, 31008 Pamplona, Spain.

Silvestre Vicent (S)

Program in Solid Tumors, Center for Applied Medical Research, Program in Solid Tumors, 31008 Pamplona, Spain.
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 31008 Madrid, Spain.
IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.

Rubén Pío (R)

Program in Solid Tumors, Center for Applied Medical Research, Program in Solid Tumors, 31008 Pamplona, Spain.
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 31008 Madrid, Spain.
IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.
Department of Biochemistry and Genetics, School of Sciences, University of Navarra, 31008 Pamplona, Spain.

Juan José Lasarte (JJ)

Program of Immunology and Immunotherapy, Center for Applied Medical Research, Program of Immunology and Immunotherapy, 31008 Pamplona, Spain.
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 31008 Madrid, Spain.
IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.

Alfonso Calvo (A)

Program in Solid Tumors, Center for Applied Medical Research, Program in Solid Tumors, 31008 Pamplona, Spain.
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 31008 Madrid, Spain.
Department of Pathology, Anatomy and Physiology, University of Navarra, 31008 Pamplona, Spain.
IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.

Daniel Ajona (D)

Program in Solid Tumors, Center for Applied Medical Research, Program in Solid Tumors, 31008 Pamplona, Spain.
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 31008 Madrid, Spain.
IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.
Department of Biochemistry and Genetics, School of Sciences, University of Navarra, 31008 Pamplona, Spain.

Ignacio Gil-Bazo (I)

Department of Oncology, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
Program in Solid Tumors, Center for Applied Medical Research, Program in Solid Tumors, 31008 Pamplona, Spain.
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 31008 Madrid, Spain.
IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.

Classifications MeSH