The Dwindling Microbiota of Aerobic Vaginitis, an Inflammatory State Enriched in Pathobionts with Limited TLR Stimulation.

Toll-like receptor 2/6 Toll-like receptor 4 aerobic vaginitis amplicon sequence variants bacterial vaginosis dysbiosis next-generation sequencing qPCR vaginal lactobacilli vaginal microbiome

Journal

Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402

Informations de publication

Date de publication:
28 Oct 2020
Historique:
received: 03 09 2020
revised: 16 10 2020
accepted: 26 10 2020
entrez: 31 10 2020
pubmed: 1 11 2020
medline: 1 11 2020
Statut: epublish

Résumé

While bacterial vaginosis (BV) is a well-known type of vaginal dysbiosis, aerobic vaginitis (AV) is an inflammatory condition that remains understudied and under-recognised. It predisposes women to serious complications including urogenital infections and pregnancy problems. Here, we investigated the bacterial community in AV to explore its possible role in AV pathogenesis. We collected vaginal lavage fluid samples of women (

Identifiants

pubmed: 33126716
pii: diagnostics10110879
doi: 10.3390/diagnostics10110879
pmc: PMC7692151
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Universiteit Antwerpen
ID : FFB160014
Organisme : Agentschap voor Innovatie door Wetenschap en Technologie
ID : IWT-SB141198
Organisme : Agentschap voor Innovatie door Wetenschap en Technologie
ID : IWT/50052
Organisme : Fonds Wetenschappelijk Onderzoek
ID : 1S17916N
Organisme : Fonds Wetenschappelijk Onderzoek
ID : 11A0618N
Organisme : Herculesstichting
ID : UABR09004
Organisme : Herculesstichting
ID : AUHA1108

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Auteurs

Eline F M Oerlemans (EFM)

Department of Bioscience Engineering, Research Group Environmental Ecology and Applied Microbiology, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerp, Belgium.

Sander Wuyts (S)

Department of Bioscience Engineering, Research Group Environmental Ecology and Applied Microbiology, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerp, Belgium.

Gert Bellen (G)

Femicare VZW, Clinical Research for Women, Gasthuismolenstraat 33, B-3300 Tienen, Belgium.

Stijn Wittouck (S)

Department of Bioscience Engineering, Research Group Environmental Ecology and Applied Microbiology, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerp, Belgium.

Ilke De Boeck (I)

Department of Bioscience Engineering, Research Group Environmental Ecology and Applied Microbiology, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerp, Belgium.

Kateryna Ruban (K)

Femicare VZW, Clinical Research for Women, Gasthuismolenstraat 33, B-3300 Tienen, Belgium.

Camille Nina Allonsius (CN)

Department of Bioscience Engineering, Research Group Environmental Ecology and Applied Microbiology, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerp, Belgium.

Marianne F L van den Broek (MFL)

Department of Bioscience Engineering, Research Group Environmental Ecology and Applied Microbiology, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerp, Belgium.

Gilbert G G Donders (GGG)

Femicare VZW, Clinical Research for Women, Gasthuismolenstraat 33, B-3300 Tienen, Belgium.
Department of Obstetrics and Gynecology, Faculty of Medicine, University Hospital Antwerp, Wilrijkstraat 10, B-2650 Edegem, Belgium.

Sarah Lebeer (S)

Department of Bioscience Engineering, Research Group Environmental Ecology and Applied Microbiology, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerp, Belgium.

Classifications MeSH