Electroceuticals in the Gastrointestinal Tract.

Electric Stimulation Gastrointestinal Diseases Humans Pharmaceutical Preparations
electrical stimulation electroceuticals gastrointestinal tract

Journal

Trends in pharmacological sciences
ISSN: 1873-3735
Titre abrégé: Trends Pharmacol Sci
Pays: England
ID NLM: 7906158

Informations de publication

Date de publication:
12 2020
Historique:
received: 02 06 2020
revised: 25 09 2020
accepted: 30 09 2020
pubmed: 1 11 2020
medline: 26 8 2021
entrez: 31 10 2020
Statut: ppublish

Résumé

The field of electroceuticals has attracted considerable attention over the past few decades as a novel therapeutic modality. The gastrointestinal (GI) tract (GIT) holds significant potential as a target for electroceuticals as the intersection of neural, endocrine, and immune systems. We review recent developments in electrical stimulation of various portions of the GIT (including esophagus, stomach, and small and large intestine) and nerves projecting to the GIT and supportive organs. This has been tested with varying degrees of success for several dysmotility, inflammatory, hormonal, and neurologic disorders. We outline a vision for the future of GI electroceuticals, building on advances in mechanistic understanding of GI physiology coupled with novel ingestible technologies. The next wave of electroceutical therapies will be minimally invasive and more targeted than current approaches, making them an indispensable tool in the clinical armamentarium.

Identifiants

DOI: 10.1016/j.tips.2020.09.014 PMID: 33127099 PMC: PMC8186669
pubmed: 33127099
pii: S0165-6147(20)30221-2
doi: 10.1016/j.tips.2020.09.014
pmc: PMC8186669
mid: NIHMS1676822
pii:
doi:

Substances chimiques

Pharmaceutical Preparations 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

960-976

Subventions

Organisme : NIDDK NIH HHS
ID : F32 DK122762
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB000244
Pays : United States
Organisme : NIBIB NIH HHS
ID : R37 EB000244
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

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Auteurs

Khalil B Ramadi (KB)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Shriya S Srinivasan (SS)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Giovanni Traverso (G)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: cgt20@mit.edu.

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Stimulation physique › Stimulation électrique › Electroceuticals in the Gastrointestinal Tract.
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Electroceuticals in the Gastrointestinal Tract.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Electroceuticals in the Gastrointestinal Tract.
questionsmedicales.fr › Préparations pharmaceutiques › Electroceuticals in the Gastrointestinal Tract.