Cytokine saga in visceral leishmaniasis.
Cell-mediated immunity
Leishmania
Progression and resolution, Cytokines
T cells
Visceral leishmaniasis
Journal
Cytokine
ISSN: 1096-0023
Titre abrégé: Cytokine
Pays: England
ID NLM: 9005353
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
18
05
2020
revised:
21
09
2020
accepted:
25
09
2020
pubmed:
1
11
2020
medline:
19
2
2022
entrez:
31
10
2020
Statut:
ppublish
Résumé
In humans, infection with Leishmania manifests into a spectrum of diseases. The manifestation of the diseases depend on the resultant evasion of the parasite to immune responses namely by macrophages, which is an exclusive host of Leishmania. The B cells valiantly mount antibody responses, however, to no avail as the Leishmania parasites occupy the intracellular niches of the macrophages and subvert the immune response. Extensive studies have been documented on the role of cell-mediated immunity (CMI) in protection and counter survival strategies of the parasites leading to downregulation of CMI. The present review attempts to discuss the cytokines in progression or resolution of visceral form of leishmaniasis or kala-azar, predominantly affecting the Indian subcontinent. The components/cytokine(s) responsible for the regulation of the critical balance of T helper cells and their subsets have been discussed in the perspective. Therefore, any strategy involving the treatment of visceral leishmania (VL) needs to consider the balance and regulation of T cell function.
Identifiants
pubmed: 33127259
pii: S1043-4666(20)30338-0
doi: 10.1016/j.cyto.2020.155322
pii:
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
155322Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.