Kinetics of Bacterial Inactivation by Peroxynitric Acid in the Presence of Organic Contaminants.

Amino Acids / pharmacology Anti-Bacterial Agents / pharmacology Bacillus subtilis / drug effects Disinfectants / pharmacology Disinfection / methods Enterococcus faecium / drug effects Escherichia coli / drug effects Hypochlorous Acid / pharmacology Kinetics Nitrates / pharmacology Serum Albumin, Bovine / pharmacology
Chick-Watson's law amino acid residues disinfection kinetics analysis organic contaminants peroxynitric acid reactive oxygen and nitrogen species

Journal

Applied and environmental microbiology
ISSN: 1098-5336
Titre abrégé: Appl Environ Microbiol
Pays: United States
ID NLM: 7605801

Informations de publication

Date de publication:
04 01 2021
Historique:
received: 05 08 2020
accepted: 26 10 2020
pubmed: 1 11 2020
medline: 30 3 2021
entrez: 31 10 2020
Statut: epublish

Résumé

Low-temperature atmospheric-pressure plasma has been studied for disinfection purposes. When plasma is exposed to water, reactive oxygen and nitrogen species are generated and preserved in the water fraction (plasma-treated water [PTW]), which consequently exhibits bactericidal activity. At low temperatures, one of the bactericidal components of PTW is peroxynitric acid (PNA). Importantly, PNA can also be synthesized by chemical reaction, without exposure to plasma. In this study, we evaluated the bactericidal properties of PNA based on reaction kinetics in comparison with other disinfectants. The analysis, based on dose-dependent effects, showed that PNA exhibited about 1 and 10 times the bactericidal activity of hypochlorous acid (HOCl) and peracetic acid, respectively. In addition, we evaluated the influence of organic contaminants on the bactericidal effects of PNA and HOCl. The bactericidal potential of both disinfectants was reduced by bovine serum albumin (BSA); however, PNA showed about 30-times-higher resistance against BSA inhibition than HOCl. Analysis of the dose-dependent effects of PNA revealed that the inhibition of bactericidal effect was caused by its consumption. Further experiments using model substrates containing particular amino acid residues (Met, Cys, Lys, and Leu) suggested that the bacterial inactivation by PNA is less affected by BSA due to the low reactivity and narrow reactivity spectrum of PNA for amino acid residues. Overall, our results suggest that PNA has a great disinfection potential, especially in the presence of organic contaminants (e.g., on the surface of the human body and on medical instruments contaminated with biological fluids).

Identifiants

DOI: 10.1128/AEM.01860-20 PMID: 33127816 PMC: PMC7783340
pubmed: 33127816
pii: AEM.01860-20
doi: 10.1128/AEM.01860-20
pmc: PMC7783340
pii:
doi:

Substances chimiques

Amino Acids 0
Anti-Bacterial Agents 0
Disinfectants 0
Nitrates 0
peroxynitric acid 26404-66-0
Serum Albumin, Bovine 27432CM55Q
Hypochlorous Acid 712K4CDC10

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2021 American Society for Microbiology.

Références

Lett Appl Microbiol. 2009 Jan;48(1):13-8
pubmed: 19170858
Mol Immunol. 2012 Oct;52(3-4):174-82
pubmed: 22677715
Dent Mater J. 2017 Jul 26;36(4):422-428
pubmed: 28367914
J Pharm Sci. 2005 Feb;94(2):304-16
pubmed: 15570599
Front Microbiol. 2018 Jul 09;9:1522
pubmed: 30038607
Chem Res Toxicol. 2020 Jul 20;33(7):1633-1643
pubmed: 32298095
J Hyg (Lond). 1908 Sep;8(4):536-42
pubmed: 20474372
Appl Environ Microbiol. 1996 Feb;62(2):545-51
pubmed: 8593054
Environ Sci Technol. 2017 May 2;51(9):4870-4876
pubmed: 28296395
Aust Endod J. 2008 Apr;34(1):19-24
pubmed: 18352899
Int J Food Microbiol. 1994 Nov;23(3-4):449-65
pubmed: 7873343
Chem Res Toxicol. 2001 Oct;14(10):1453-64
pubmed: 11599938
Dent Mater J. 2019 Jul 31;38(4):654-662
pubmed: 31189796
IARC Monogr Eval Carcinog Risks Hum. 2006;88:1-478
pubmed: 17366697
Dent Mater J. 2011;30(3):384-91
pubmed: 21597211
J Chromatogr A. 2016 Jan 29;1431:89-93
pubmed: 26748867
J Oral Biosci. 2020 Jun;62(2):189-194
pubmed: 32272186
J Hyg (Lond). 1908 Jan;8(1):92-158
pubmed: 20474353
Am J Infect Control. 2019 Jun;47S:A96-A105
pubmed: 31146858
Water Res. 2004 Feb;38(4):1069-77
pubmed: 14769428
J Endod. 2010 Feb;36(2):268-71
pubmed: 20113787
Br J Dermatol. 2010 Jul;163(1):78-82
pubmed: 20222930
J Appl Microbiol. 2002;92 Suppl:16S-27S
pubmed: 12000609
Dalton Trans. 2009 Aug 7;(29):5730-6
pubmed: 20449087
Appl Environ Microbiol. 2010 Nov;76(22):7662-4
pubmed: 20889799
J Appl Microbiol. 1999 Nov;87(5):782-6
pubmed: 10594721

Auteurs

Takashi Yokoyama (T)

Center for Atomic and Molecular Technologies, Graduate School of Engineering, Osaka University, Suita, Osaka, Japan yokoyama@ppl.eng.osaka-u.ac.jp.
ORCID: 0000-0003-1268-7404

Shinya Miyazaki (S)

Center for Atomic and Molecular Technologies, Graduate School of Engineering, Osaka University, Suita, Osaka, Japan.

Hiroko Akagi (H)

Center for Atomic and Molecular Technologies, Graduate School of Engineering, Osaka University, Suita, Osaka, Japan.

Satoshi Ikawa (S)

Osaka Research Institute of Industrial Science and Technology, Izumi, Osaka, Japan.

Katsuhisa Kitano (K)

Center for Atomic and Molecular Technologies, Graduate School of Engineering, Osaka University, Suita, Osaka, Japan.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Kinetics of Bacterial Inactivation by...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Kinetics of Bacterial Inactivation by...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets sporulés à Gram positif › Bacillaceae › Bacillus › Bacillus subtilis › Kinetics of Bacterial Inactivation by...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Désinfectants › Kinetics of Bacterial Inactivation by...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pratiques en santé publique › Contrôle des maladies transmissibles › Prévention des infections › Stérilisation › Désinfection › Kinetics of Bacterial Inactivation by...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Lactobacillales › Enterococcaceae › Enterococcus › Enterococcus faecium › Kinetics of Bacterial Inactivation by...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Kinetics of Bacterial Inactivation by...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Acide hypochloreux › Kinetics of Bacterial Inactivation by...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › Kinetics of Bacterial Inactivation by...
questionsmedicales.fr › Composés chimiques organiques › Nitrates › Kinetics of Bacterial Inactivation by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Sérumalbumine › Sérumalbumine bovine › Kinetics of Bacterial Inactivation by...