Conventional and Genetic Evidence on the Association between Adiposity and CKD.
Adiposity
/ genetics
Adult
Aged
Algorithms
Body Mass Index
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Mendelian Randomization Analysis
Middle Aged
Obesity
/ complications
Prevalence
Prospective Studies
Renal Insufficiency, Chronic
/ genetics
Risk Factors
United Kingdom
Waist-Hip Ratio
Mendelian randomization
body mass index
central adiposity
chronic kidney disease
epidemiology and outcomes
obesity
Journal
Journal of the American Society of Nephrology : JASN
ISSN: 1533-3450
Titre abrégé: J Am Soc Nephrol
Pays: United States
ID NLM: 9013836
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
18
05
2020
accepted:
10
09
2020
pubmed:
1
11
2020
medline:
8
7
2021
entrez:
31
10
2020
Statut:
ppublish
Résumé
The size of any causal contribution of central and general adiposity to CKD risk and the underlying mechanism of mediation are unknown. Data from 281,228 UK Biobank participants were used to estimate the relevance of waist-to-hip ratio and body mass index (BMI) to CKD prevalence. Conventional approaches used logistic regression. Genetic analyses used Mendelian randomization (MR) and data from 394 waist-to-hip ratio and 773 BMI-associated loci. Models assessed the role of known mediators (diabetes mellitus and BP) by adjusting for measured values (conventional analyses) or genetic associations of the selected loci (multivariable MR). Evidence of CKD was found in 18,034 (6.4%) participants. Each 0.06 higher measured waist-to-hip ratio and each 5-kg/m Genetic analyses suggest that conventional associations between central and general adiposity with CKD are largely causal. However, conventional approaches underestimate mediating roles of diabetes, BP, and their correlates. Genetic approaches suggest these mediators explain most of adiposity-CKD-associated risk.
Sections du résumé
BACKGROUND
The size of any causal contribution of central and general adiposity to CKD risk and the underlying mechanism of mediation are unknown.
METHODS
Data from 281,228 UK Biobank participants were used to estimate the relevance of waist-to-hip ratio and body mass index (BMI) to CKD prevalence. Conventional approaches used logistic regression. Genetic analyses used Mendelian randomization (MR) and data from 394 waist-to-hip ratio and 773 BMI-associated loci. Models assessed the role of known mediators (diabetes mellitus and BP) by adjusting for measured values (conventional analyses) or genetic associations of the selected loci (multivariable MR).
RESULTS
Evidence of CKD was found in 18,034 (6.4%) participants. Each 0.06 higher measured waist-to-hip ratio and each 5-kg/m
CONCLUSIONS
Genetic analyses suggest that conventional associations between central and general adiposity with CKD are largely causal. However, conventional approaches underestimate mediating roles of diabetes, BP, and their correlates. Genetic approaches suggest these mediators explain most of adiposity-CKD-associated risk.
Identifiants
pubmed: 33127858
pii: 00001751-202101000-00014
doi: 10.1681/ASN.2020050679
pmc: PMC7894659
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
127-137Subventions
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U137686857
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00017/3
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U137686861
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12026/3
Pays : United Kingdom
Organisme : British Heart Foundation
ID : CH/1996001/9454
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R007764/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00017/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Informations de copyright
Copyright © 2021 by the American Society of Nephrology.
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