Orcokinin in the central complex of the locust Schistocerca gregaria: Identification of immunostained neurons and colocalization with other neuroactive substances.
RRID: AB_2307385
RRID: AB_2307443
RRID: AB_2313971
RRID: AB_2314455
RRID: AB_2314497
RRID: AB_2315017
RRID: AB_2315056
RRID: AB_2337258
RRID: AB_2337423
RRID: AB_2337925
RRID: AB_2340411
RRID: AB_2340607
RRID: AB_2340612
RRID: AB_261363
RRID: AB_477019
RRID: AB_572262
RRID: SCR_007353
RRID: SCR_014199
RRID: SCR_014235
RRID: SCR_016951
allatostatin
glutamic acid decarboxylase
immunocytochemistry
insect brain
serotonin
spatial orientation
Journal
The Journal of comparative neurology
ISSN: 1096-9861
Titre abrégé: J Comp Neurol
Pays: United States
ID NLM: 0406041
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
revised:
22
10
2020
received:
13
08
2020
accepted:
22
10
2020
pubmed:
1
11
2020
medline:
11
1
2022
entrez:
31
10
2020
Statut:
ppublish
Résumé
The central complex is a group of highly interconnected neuropils in the insect brain. It is involved in the control of spatial orientation, based on external compass cues and various internal needs. The functional and neurochemical organization of the central complex has been studied in detail in the desert locust Schistocerca gregaria. In addition to classical neurotransmitters, immunocytochemistry has provided evidence for a major contribution of neuropeptides to neural signaling within the central complex. To complement these data, we have identified all orcokinin-immunoreactive neurons in the locust central complex and associated brain areas. About 50 bilateral pairs of neurons innervating all substructures of the central complex exhibit orcokinin immunoreactivity. Among these were about 20 columnar neurons, 33 bilateral pairs of tangential neurons of the central body, and seven pairs of tangential neurons of the protocerebral bridge. In silico transcript analysis suggests the presence of eight different orcokinin-A type peptides in the desert locust. Double label experiments showed that all orcokinin-immunostained tangential neurons of the lateral accessory lobe cluster were also immunoreactive for GABA and the GABA-synthesizing enzyme glutamic acid decarboxylase. Two types of tangential neurons of the upper division of the central body were, furthermore, also labeled with an antiserum against Dip-allatostatin I. No colocalization was found with serotonin immunostaining. The data provide additional insights into the neurochemical organization of the locust central complex and suggest that orcokinin-peptides of the orcokinin-A gene act as neuroactive substances at all stages of signal processing in this brain area.
Substances chimiques
Neuropeptides
0
orcokinin
145344-97-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1876-1894Informations de copyright
© 2020 The Authors. The Journal of Comparative Neurology published by Wiley Periodicals LLC.
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