The association between cardio-respiratory fitness and incident depression: The Maastricht Study.

Cardiorespiratory Fitness Cohort Studies Depression / epidemiology Exercise Humans Physical Fitness Prospective Studies Risk Factors
Cardiorespiratory fitness Cohort Studies Prospective Studies depression incidence prospective study

Journal

Journal of affective disorders
ISSN: 1573-2517
Titre abrégé: J Affect Disord
Pays: Netherlands
ID NLM: 7906073

Informations de publication

Date de publication:
15 01 2021
Historique:
received: 07 05 2020
revised: 04 08 2020
accepted: 21 09 2020
pubmed: 1 11 2020
medline: 21 4 2021
entrez: 31 10 2020
Statut: ppublish

Résumé

Moderate to vigorous physical activity (MVPA) can help to prevent depression, but identification of the most important psycho-biological pathways involved is unclear. The improvement of cardio-respiratory fitness (CRF) in response to MVPA can vary markedly, we therefore examined the association between CRF and the incidence of depressive symptoms. We used data from The Maastricht Study, a large population-based prospective-cohort study. CRF was estimated at baseline from a graded submaximal exercise protocol and MVPA was measured with accelerometry. Depressive symptoms were assessed using the validated Dutch version of the 9-item Patient Health Questionnaire, both at baseline and during annual follow-up over five years. Cox proportional hazards models were used. A total of 1,730 individuals without depressive symptoms at baseline were included in the analysis. During the 5-year follow-up, n = 166 (9.6%) of individuals developed depressive symptoms. Compared to individuals with a low CRF, those with a moderate-to-high CRF had a significantly lower risk of developing depressive symptoms, independent of MVPA (medium CRF: HR = 0.49 (95%CI = 0.33-0.72); high CRF: HR = 0.48 (95% CI = 0.30-0.75). These associations were adjusted for age, sex, level of education, diabetes status, smoking status, alcohol use, energy intake, waist circumferences and antidepressant medications. PHQ-9 is a validated screening instrument, but it is not a diagnostic tool of depression. Higher CRF was strongly associated with a lower risk of incident depressive symptoms over 5-year follow-up, independent of the level of MVPA at baseline, suggesting that interventions aimed at improving CRF could reduce the risk of depression.

Sections du résumé

BACKGROUND
Moderate to vigorous physical activity (MVPA) can help to prevent depression, but identification of the most important psycho-biological pathways involved is unclear. The improvement of cardio-respiratory fitness (CRF) in response to MVPA can vary markedly, we therefore examined the association between CRF and the incidence of depressive symptoms.
METHODS
We used data from The Maastricht Study, a large population-based prospective-cohort study. CRF was estimated at baseline from a graded submaximal exercise protocol and MVPA was measured with accelerometry. Depressive symptoms were assessed using the validated Dutch version of the 9-item Patient Health Questionnaire, both at baseline and during annual follow-up over five years. Cox proportional hazards models were used.
RESULTS
A total of 1,730 individuals without depressive symptoms at baseline were included in the analysis. During the 5-year follow-up, n = 166 (9.6%) of individuals developed depressive symptoms. Compared to individuals with a low CRF, those with a moderate-to-high CRF had a significantly lower risk of developing depressive symptoms, independent of MVPA (medium CRF: HR = 0.49 (95%CI = 0.33-0.72); high CRF: HR = 0.48 (95% CI = 0.30-0.75). These associations were adjusted for age, sex, level of education, diabetes status, smoking status, alcohol use, energy intake, waist circumferences and antidepressant medications.
LIMITATIONS
PHQ-9 is a validated screening instrument, but it is not a diagnostic tool of depression.
CONCLUSIONS
Higher CRF was strongly associated with a lower risk of incident depressive symptoms over 5-year follow-up, independent of the level of MVPA at baseline, suggesting that interventions aimed at improving CRF could reduce the risk of depression.

Identifiants

DOI: 10.1016/j.jad.2020.09.090 PMID: 33128938
pubmed: 33128938
pii: S0165-0327(20)32786-5
doi: 10.1016/j.jad.2020.09.090
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

484-490

Informations de copyright

Copyright © 2020. Published by Elsevier B.V.

Auteurs

Vincenza Gianfredi (V)

School of Public Health, University Vita-Salute San Raffaele, Milan, Italy; CARIM School for Cardiovascular Diseases, Maastricht University, Medical Center+, Maastricht, the Netherlands; CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, the Netherlands; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa, Genoa, Italy. Electronic address: v.gianfredi@maastrichtuniversity.nl.

Annemarie Koster (A)

CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, the Netherlands; Department of Social Medicine, Maastricht University, Maastricht, the Netherlands; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa, Genoa, Italy. Electronic address: a.koster@maastrichtuniversity.nl.

Simone J P M Eussen (SJPM)

CARIM School for Cardiovascular Diseases, Maastricht University, Medical Center+, Maastricht, the Netherlands; Department of Epidemiology, Maastricht University, Maastricht, the Netherlands. Electronic address: simone.eussen@maastrichtuniversity.nl.

Anna Odone (A)

School of Public Health, University Vita-Salute San Raffaele, Milan, Italy. Electronic address: odone.anna@hsr.it.

Andrea Amerio (A)

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa, Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, Italy; Mood Disorders Program, Tufts Medical Center, Boston, MA, United States. Electronic address: andrea.amerio@unige.it.

Carlo Signorelli (C)

School of Public Health, University Vita-Salute San Raffaele, Milan, Italy. Electronic address: signorelli.carlo@hsr.it.

Coen D A Stehouwer (CDA)

CARIM School for Cardiovascular Diseases, Maastricht University, Medical Center+, Maastricht, the Netherlands; Department of Internal Medicine, Maastricht University Medical Center+, Maastricht, the Netherlands. Electronic address: cda.stehouwer@mumc.nl.

Hans H C M Savelberg (HHCM)

Department of Nutrition and Movement Sciences, Maastricht University, Maastricht, the Netherlands; School of Health Professions Education, Maastricht University, Maastricht, the Netherlands; NUTRIM, School for Nutrition and Translation Research Maastricht, Maastricht University, the Netherlands. Electronic address: hans.savelberg@maastrichtuniversity.nl.

Anke Wesselius (A)

NUTRIM, School for Nutrition and Translation Research Maastricht, Maastricht University, the Netherlands; Department of Complex Genetics, Maastricht University, Maastricht, the Netherlands. Electronic address: anke.wesselius@maastrichtuniversity.nl.

Sebastian Köhler (S)

Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, the Netherlands; MHeNS School for Mental Health and Neuroscience, Maastricht University Medical Center+, Maastricht, the Netherlands. Electronic address: s.koehler@maastrichtuniversity.nl.

Miranda T Schram (MT)

CARIM School for Cardiovascular Diseases, Maastricht University, Medical Center+, Maastricht, the Netherlands; Department of Internal Medicine, Maastricht University Medical Center+, Maastricht, the Netherlands; The Netherlands Heart and Vascular Center, Maastricht University Medical Center+, Maastricht, the Netherlands. Electronic address: m.schram@maastrichtuniversity.nl.

Nicolaas C Schaper (NC)

CARIM School for Cardiovascular Diseases, Maastricht University, Medical Center+, Maastricht, the Netherlands; CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, the Netherlands; Department of Internal Medicine, Maastricht University Medical Center+, Maastricht, the Netherlands. Electronic address: n.schaper@mumc.nl.

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Classifications MeSH

questionsmedicales.fr › Caractéristiques de la population › Santé › Aptitude physique › Capacité cardiorespiratoire › The association between cardio-respiratory...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › The association between cardio-respiratory...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Dépression › The association between cardio-respiratory...
questionsmedicales.fr › Activités humaines › Exercice physique › The association between cardio-respiratory...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The association between cardio-respiratory...
questionsmedicales.fr › Caractéristiques de la population › Santé › Aptitude physique › The association between cardio-respiratory...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › The association between cardio-respiratory...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › The association between cardio-respiratory...