Carbon nitride-based nanocaptor: An intelligent nanosystem with metal ions chelating effect for enhanced magnetic targeting phototherapy of Alzheimer's disease.
Alzheimer's disease
Aβ aggregation clearance
Blood-brain barrier
Copper ions capture
Intelligent nanocaptors
Targeted synergistic therapy
Journal
Biomaterials
ISSN: 1878-5905
Titre abrégé: Biomaterials
Pays: Netherlands
ID NLM: 8100316
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
11
06
2020
revised:
29
09
2020
accepted:
20
10
2020
pubmed:
1
11
2020
medline:
25
5
2021
entrez:
31
10
2020
Statut:
ppublish
Résumé
Metal ions imbalance, a well-established pathologic feature of alzheimer's disease (AD), ultimately results in the deposition of amyloid-β peptide (Aβ) proteins and Aβ-induced neurotoxicity. Herein, to overcome these hurdles, an intelligent Aβ nanocaptor with the capacity to chelate metal ions and targeted therapy is developed by anchoring carbon nitride (C
Identifiants
pubmed: 33129186
pii: S0142-9612(20)30729-8
doi: 10.1016/j.biomaterials.2020.120483
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Ions
0
Nitriles
0
cyanogen
534Q0F66RK
Copper
789U1901C5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
120483Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.