Depression: An actionable outcome for those at clinical high-risk.
Clinical high-risk
Depression
Prognosis
Psychosis
Symptoms
Journal
Schizophrenia research
ISSN: 1573-2509
Titre abrégé: Schizophr Res
Pays: Netherlands
ID NLM: 8804207
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
27
03
2020
revised:
29
07
2020
accepted:
01
10
2020
pubmed:
2
11
2020
medline:
22
6
2021
entrez:
1
11
2020
Statut:
ppublish
Résumé
Comorbid diagnoses are common in youth who are at clinical high-risk (CHR) for developing psychosis, with depression being the most common. The aim of this paper is to examine depression over two years in a large sample of CHR youth who do not make the transition to psychosis, considering both categorical and dimensional ratings of depression severity. The sample consisted of 267 CHR youth who were followed for two years. Based on DSM-IV diagnoses over this time period, 100 CHR individuals never received a diagnosis of depression, 64 individuals continuously met criteria for depression, 92 individuals received a diagnosis of depression at one or more timepoints, and 11 participants had a diagnosis of depression only at 24-months. These groupings were supported by six-monthly ratings on the Calgary Depression Scale. The majority of this sample experienced a major depressive episode on more than one occasion, suggesting that depression and depressive symptoms identify a domain of substantial unmet clinical need. Recommendations are that depression in CHR youth and young adults should be monitored more frequently and that there is a need for clinical trials to address depression systematically in this vulnerable population.
Identifiants
pubmed: 33129638
pii: S0920-9964(20)30488-6
doi: 10.1016/j.schres.2020.10.001
pmc: PMC7854482
mid: NIHMS1644244
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
38-43Subventions
Organisme : NIMH NIH HHS
ID : U01 MH066069
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH081984
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH082022
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors have declared that there are no conflicts of interest with respect to this paper.
Références
Schizophr Res. 1990 Jul-Aug;3(4):247-51
pubmed: 2278986
Psychol Med. 2019 Jul;49(10):1670-1677
pubmed: 30176955
Acta Psychiatr Scand. 1998 Jan;97(1):36-41
pubmed: 9504701
Am J Psychiatry. 2020 Feb 1;177(2):164-171
pubmed: 31509005
Curr Treat Options Psychiatry. 2019 Mar;6(1):1-16
pubmed: 31403023
Schizophr Res. 2004 Jun 1;68(2-3):349-56
pubmed: 15099616
Schizophr Res. 2018 May;195:579-580
pubmed: 28964651
Schizophr Bull. 2018 Feb 15;44(2):254-263
pubmed: 29036402
Schizophr Res. 1992 Mar;6(3):201-8
pubmed: 1571313
Schizophr Res. 2012 Dec;142(1-3):77-82
pubmed: 23043872
J Affect Disord. 2000 May;58(2):107-15
pubmed: 10781700
J Psychiatr Res. 1999 Sep-Oct;33(5):433-43
pubmed: 10504012
Schizophr Res. 2017 Dec;190:90-95
pubmed: 28372906
Schizophr Res. 1994 Feb;11(3):239-44
pubmed: 8193062
Schizophr Res. 2014 Mar;153(1-3):64-7
pubmed: 24439270
J Clin Psychiatry. 1998;59 Suppl 12:41-5
pubmed: 9766619
Eur Psychiatry. 2017 Feb;40:65-75
pubmed: 27992836
Schizophr Res. 1996 May;20(1-2):205-9
pubmed: 8794511
Schizophr Res. 2020 Apr 16;:
pubmed: 32307261
Schizophr Res. 1996 May;19(2-3):205-12
pubmed: 8789919
Soc Psychiatry Psychiatr Epidemiol. 2016 Feb;51(2):247-57
pubmed: 26643940
Schizophr Bull. 2014 Jan;40(1):120-31
pubmed: 23180756
Br J Psychiatry. 2015 Sep;207(3):198-206
pubmed: 26329563
Early Interv Psychiatry. 2017 Dec;11(6):480-487
pubmed: 26456932
Front Psychiatry. 2017 Oct 23;8:209
pubmed: 29109690
Psychiatry Res. 2017 Nov;257:431-437
pubmed: 28837932
Schizophr Bull. 2018 Feb 15;44(2):286-296
pubmed: 29036587
JAMA Psychiatry. 2016 Dec 1;73(12):1239-1248
pubmed: 27806157
Schizophr Res. 2018 Feb;192:357-363
pubmed: 28578922
Arch Gen Psychiatry. 2012 Mar;69(3):220-9
pubmed: 22393215
Schizophr Res. 2002 Oct 1;57(2-3):307
pubmed: 12223263
NPJ Schizophr. 2020 Oct 5;6(1):27
pubmed: 33020486